2008
Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications
Hasina R, Whipple M, Martin L, Kuo W, Ohno-Machado L, Lingen M. Angiogenic heterogeneity in head and neck squamous cell carcinoma: biological and therapeutic implications. Laboratory Investigation 2008, 88: 342-353. PMID: 18283272, PMCID: PMC2614382, DOI: 10.1038/labinvest.2008.6.Peer-Reviewed Original Research
2003
Classification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study.
Kuo W, Hasina R, Ohno-Machado L, Lingen M. Classification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study. Dental Journal 2003, 69: 23-6. PMID: 12703240.Peer-Reviewed Original ResearchConceptsGene expression profilesHuman Genome ProjectOral squamous cell carcinomaExpression profilesIdentification of genesGenome ProjectDNA microarraysMolecular networksFive-year survival rateSquamous cell carcinomaCurrent treatment strategiesGenesAggressive malignancyCell carcinomaOral cancerPreliminary studyTreatment strategiesCytologic changesEarly diagnosisSurvival rateCancerMicroarrayStatistical algorithmsCarcinomaMalignancy
2002
Gene expression profiling by DNA microarrays and its application to dental research
Kuo W, Whipple M, Sonis S, Ohno-Machado L, Jenssen T. Gene expression profiling by DNA microarrays and its application to dental research. Oral Oncology 2002, 38: 650-656. PMID: 12353490, DOI: 10.1016/s1368-8375(02)00013-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGenome-wide gene expression studiesMicroarray technologyThousands of genesVariety of genesDNA microarray technologyGene expression studiesDisease-specific genesGene expression profilingGenetic profileGene discoveryMolecular functioningSpecific genesExpression profilingDNA microarraysExpression studiesMolecular geneticsIncorporation of DNAGenesIndividual patient's genetic profileDNAComplicated networkDisease statesDrug developmentNormal functioningMRNA expressionGene expression levels in different stages of progression in oral squamous cell carcinoma.
Kuo W, Jenssen T, Park P, Lingen M, Hasina R, Ohno-Machado L. Gene expression levels in different stages of progression in oral squamous cell carcinoma. AMIA Annual Symposium Proceedings 2002, 415-9. PMID: 12474876, PMCID: PMC2244435.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellDisease ProgressionGene ExpressionHumansMouth NeoplasmsNeoplasm StagingConceptsOral squamous cell carcinomaExpression levelsGene expression studiesGene expression dataGene expression levelsChromosome domainsCancer samplesExpression studiesSquamous cell carcinomaMolecular mechanismsExpression dataGenesMolecular levelProgression of OSCCCell carcinomaGenetic featuresCancer typesCommon cancer typesImportant insightsSignificant differencesSmall panelPatient samplesDifferent stagesProgressionSample types