2011
A Primer on the Current State of Microarray Technologies
Trachtenberg A, Robert J, Abdalla A, Fraser A, He S, Lacy J, Rivas-Morello C, Truong A, Hardiman G, Ohno-Machado L, Liu F, Hovig E, Kuo W. A Primer on the Current State of Microarray Technologies. Methods In Molecular Biology 2011, 802: 3-17. PMID: 22130870, DOI: 10.1007/978-1-61779-400-1_1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMicroarray technologyGenome-wide gene expression studiesAvailability of microarraysVariety of genesThousands of genesDNA microarray technologyDisease-specific genesGene expression studiesGene discoveryMolecular functioningExpression studiesGene expressionMolecular geneticsGenesComputer science analysisMicroarrayComplicated networkDisease statesDrug developmentNormal functioningMassive levelsDisease diagnosisGeneticsField of microarraysHigh levels
2007
Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates
Liu F, Jenssen T, Trimarchi J, Punzo C, Cepko C, Ohno-Machado L, Hovig E, Patrick Kuo W. Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates. BMC Genomics 2007, 8: 153. PMID: 17555589, PMCID: PMC1899500, DOI: 10.1186/1471-2164-8-153.Peer-Reviewed Original ResearchConceptsDNA microarray platformMicroarray platformSequencing-based approachesSequencing-based technologiesGene expression technologyGene expression profilingTranscriptome profilingBiological replicatesExpression profilingExpression technologyGene expressionDifferential expressionBiomarker discoveryProfilingExpressionMicroarrayImportant tool
2004
Deciphering gene expression profiles generated from DNA microarrays and their applications in oral medicine
Kuo W, Whipple M, Epstein J, Jenssen T, Santos G, Ohno-Machado L, Sonis S. Deciphering gene expression profiles generated from DNA microarrays and their applications in oral medicine. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2004, 97: 584-591. PMID: 15153870, DOI: 10.1016/j.tripleo.2003.11.016.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGene expression profilesTranscriptional mappingDNA microarraysExpression profilesGenome-wide monitoringThousands of genesApplication of microarraysTypical microarray experimentTranscription levelsBiological processesGenetic changesMicroarray technologyMicroarray experimentsDiseased cellsMicroarrayRelative expressionDisease etiologyNew therapeutic toolsWidespread hopeCellsGenesNew biomarkersTherapeutic toolExpressionDiscovery
2003
Microarrays and clinical dentistry
Kuo W, Whipple M, Jenssen T, Todd R, Epstein J, Ohno-Machado L, Sonis S, Park P. Microarrays and clinical dentistry. The Journal Of The American Dental Association 2003, 134: 456-462. PMID: 12733779, DOI: 10.14219/jada.archive.2003.0195.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdvanced microarray technologiesEntire human genomeActivity of genesGene expression patternsHuman Genome ProjectGenome levelHuman genomeGenetic approachesCellular developmentDNA sequencesGenome ProjectExciting biologyCandidate genesExpression patternsMicroarray technologyMicroarrayNumber of cancersGenesMolecular profileAnalysis of diseasesMolecular behaviorGenomeBiologyTissue samplesProteinClassification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study.
Kuo W, Hasina R, Ohno-Machado L, Lingen M. Classification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study. Dental Journal 2003, 69: 23-6. PMID: 12703240.Peer-Reviewed Original ResearchConceptsGene expression profilesHuman Genome ProjectOral squamous cell carcinomaExpression profilesIdentification of genesGenome ProjectDNA microarraysMolecular networksFive-year survival rateSquamous cell carcinomaCurrent treatment strategiesGenesAggressive malignancyCell carcinomaOral cancerPreliminary studyTreatment strategiesCytologic changesEarly diagnosisSurvival rateCancerMicroarrayStatistical algorithmsCarcinomaMalignancy