2022
Association of Renin-Angiotensin-Aldosterone System Inhibitor Usage Patterns with Midterm Amputation-Free Survival after Lower Extremity Bypass for Peripheral Arterial Disease
Naazie I, Arhuidese I, Abdelgawwad M, Unkart J, Conte M, Malas M. Association of Renin-Angiotensin-Aldosterone System Inhibitor Usage Patterns with Midterm Amputation-Free Survival after Lower Extremity Bypass for Peripheral Arterial Disease. Annals Of Vascular Surgery 2022, 88: 79-89. PMID: 36028182, DOI: 10.1016/j.avsg.2022.07.022.Peer-Reviewed Original ResearchConceptsRenin-angiotensin-aldosterone system inhibitor useRenin-angiotensin-aldosterone system inhibitorsLower extremity bypassAmputation-free survivalPeripheral arterial diseaseArtery diseaseAssociated with improved 30-day mortalityAssociated with improved survivalAssociated with 2.8-foldPeripheral arterial disease patientsLEB outcomesArtery disease patientsLower-extremity bypassSurvival benefitSystem inhibitorsPostoperative periodRAAS inhibitionStudy cohortCox regressionPrimary outcomePotential confoundersIncreased oddsDisease patientsPatientsMortality
2019
Survival after major lower extremity amputation in patients with end-stage renal disease
Arhuidese I, Nejim B, Aji E, Canner J, Malas M. Survival after major lower extremity amputation in patients with end-stage renal disease. Journal Of Vascular Surgery 2019, 70: 1291-1298. PMID: 31543169, DOI: 10.1016/j.jvs.2018.12.055.Peer-Reviewed Original ResearchConceptsKnee amputeesKnee amputationBurden of peripheral artery diseaseLower extremity amputationEstimates of life expectancyEnd-stage renal diseaseRisk-adjusted mortalityAmputation levelExtremity amputationRace-specific differencesRT recipientsHealthcare providersPeripheral arterial diseaseHD patientsLong-term mortalityUnited States Renal Data SystemMedian survivalBKAKneeHispanicsLife expectancyRenal transplantationMLEAAmputationCardiovascular diseaseOutcomes of Infrainguinal Lower Extremity Bypass Are Superior in Kidney Transplant Recipients Than Patients with Dialysis
Nejim B, Hicks C, Arhuidese I, Locham S, Dakour-Aridi H, Malas M. Outcomes of Infrainguinal Lower Extremity Bypass Are Superior in Kidney Transplant Recipients Than Patients with Dialysis. Annals Of Vascular Surgery 2019, 63: 209-217. PMID: 31349053, DOI: 10.1016/j.avsg.2019.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalBlood Vessel Prosthesis ImplantationDatabases, FactualFemaleHumansKidney Failure, ChronicKidney TransplantationLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Arterial DiseaseProgression-Free SurvivalRenal DialysisRetrospective StudiesRisk FactorsSaphenous VeinTime FactorsVascular PatencyConceptsLower extremity bypassEnd-stage renal diseaseKT recipientsPrimary patencyDialysis therapyAmputation-free survivalKidney transplantationVascular Quality Initiative databaseRisk-adjusted hazardsKidney transplant recipientsPositive effects of KTRisk of mortalityEffects of KTRisk of amputationLower-extremity bypassSurgical outcomesTransplant recipientsBaseline characteristicsBypass proceduresDialysis patientsRenal diseaseComparative efficacyKT groupDT groupPatients
2018
Infrainguinal bypass surgery outcomes are worse in hemodialysis patients compared with patients with renal transplants
Arhuidese I, Nejim B, Locham S, Malas M. Infrainguinal bypass surgery outcomes are worse in hemodialysis patients compared with patients with renal transplants. Journal Of Vascular Surgery 2018, 69: 850-856. PMID: 30583904, DOI: 10.1016/j.jvs.2018.05.252.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood Vessel Prosthesis ImplantationDatabases, FactualFemaleHumansKidney Failure, ChronicKidney TransplantationLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Arterial DiseasePostoperative ComplicationsRenal DialysisRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesVascular PatencyConceptsInfrainguinal bypass surgeryRenal transplantationRT patientsPatient survivalOutcome of infrainguinal bypass surgeryHD patientsBenefits of renal transplantationLimb salvageEnd-stage renal diseaseCox regression analysisLong-term outcomesEvaluate 30-dayRisk-adjusted analysisPopulation-based cohortCritical limb ischemiaU.S. Renal Data SystemRetrospective reviewBypass surgeryKaplan-MeierSurgery outcomesPatient-level riskRenal diseaseHemodialysis patientsLimb ischemiaPatientsOutcomes of lower extremity bypass surgery in patients with renal transplants
Arhuidese I, Nejim B, Craig-Schapiro R, Rizwan M, Malas M. Outcomes of lower extremity bypass surgery in patients with renal transplants. Journal Of Vascular Surgery 2018, 68: 1833-1840.e2. PMID: 30470370, DOI: 10.1016/j.jvs.2017.12.086.Peer-Reviewed Original ResearchMeSH KeywordsAgedBioprosthesisBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationFemaleHumansKidney TransplantationLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Arterial DiseasePostoperative ComplicationsRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesVascular PatencyVeinsConceptsOutcome of infrainguinal bypass surgeryInfrainguinal bypass surgeryPrimary assisted patencyRenal transplant patientsLong-term outcomesAssisted patencySecondary patencyTransplant patientsRenal transplantationProsthetic conduitLimb salvageBypass surgeryCohort of renal transplant patientsLower extremity bypass surgeryCox regression analysisEvaluate 30-dayMortality of patientsRisk-adjusted analysisUnited States Renal Data SystemPopulation-based cohortCritical limb ischemiaPopliteal-tibial bypassPrimary patencyRetrospective reviewAutogenous bypassAggressive infrainguinal revascularization in renal transplant patients is justifiable
Craig-Schapiro R, Nejim B, Arhuidese I, Malas M. Aggressive infrainguinal revascularization in renal transplant patients is justifiable. American Journal Of Transplantation 2018, 18: 1718-1725. PMID: 29288558, DOI: 10.1111/ajt.14636.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalFemaleFollow-Up StudiesHumansKidney Failure, ChronicKidney TransplantationLimb SalvageLower ExtremityMaleMiddle AgedPatient SelectionPostoperative ComplicationsPrognosisReoperationRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTime FactorsVascular GraftingVascular PatencyConceptsCritical limb ischemiaRenal transplant patientsTransplant patientsNontransplant patientsLimb ischemiaPrimary patencyInfrainguinal revascularizationRisk factorsMultivariate Cox regression analysisVascular Quality Initiative databaseEnd-stage renal diseaseDistal bypassCox regression analysisOutcomes of lower extremity revascularizationPrimary patency lossLower extremity revascularizationAmputation-free survivalLimb salvage outcomesAssociated with limb lossOverall survivalProsthetic conduitVein conduitPatency lossRenal diseaseInfrainguinal bypass
2017
Sex-based outcomes of lower extremity bypass surgery in hemodialysis patients
Arhuidese I, Kernodle A, Nejim B, Locham S, Hicks C, Malas M. Sex-based outcomes of lower extremity bypass surgery in hemodialysis patients. Journal Of Vascular Surgery 2017, 68: 153-160. PMID: 29276108, DOI: 10.1016/j.jvs.2017.10.063.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationChi-Square DistributionClinical Decision-MakingDatabases, FactualDisease-Free SurvivalFemaleGraft Occlusion, VascularHumansKaplan-Meier EstimateKidney DiseasesLimb SalvageLogistic ModelsLower ExtremityMaleMiddle AgedMultivariate AnalysisOdds RatioPeripheral Arterial DiseaseProportional Hazards ModelsProsthesis DesignRenal DialysisRetrospective StudiesRisk FactorsSex FactorsTime FactorsTreatment OutcomeVascular PatencyVeinsConceptsAcute graft failureAutogenous conduitGraft failureProsthetic conduitBypass surgeryHemodialysis patientsAssociated with higher patencyLimb salvagePrimary assisted patencySex-based outcomesInfrainguinal bypass surgeryLower extremity bypass surgeryCox regression analysisPatient survival ratesRisk-adjusted analysisUnited States Renal Data SystemCritical limb ischemiaAssisted patencySecondary patencyConduit usePrimary patencySurgical outcomesNo significant differenceKaplan-MeierComparing patientsRegional variation in the cost of infrainguinal lower extremity bypass surgery in the United States
Nejim B, Wang S, Arhuidese I, Obeid T, Alshaikh H, Aridi H, Locham S, Malas M. Regional variation in the cost of infrainguinal lower extremity bypass surgery in the United States. Journal Of Vascular Surgery 2017, 67: 1170-1180.e4. PMID: 29074114, DOI: 10.1016/j.jvs.2017.08.055.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionCost-Benefit AnalysisDatabases, FactualFemaleHealth ExpendituresHealthcare DisparitiesHospital CostsHumansLinear ModelsLower ExtremityMaleMiddle AgedModels, EconomicPeripheral Arterial DiseasePractice Patterns, Physicians'Process Assessment, Health CareRetrospective StudiesSurgeonsTreatment OutcomeUnited StatesVascular GraftingConceptsLower extremity bypassIn-hospital costsHospital factorsService-specific costsInfrainguinal lower extremity bypassHealth care expendituresMedian in-hospital costsGeneralized linear regression modelsLower extremity bypass surgeryHealth systemPeripheral arterial diseaseStandard revascularization proceduresPatient's clinical conditionIdentified adult patientsLinear regression modelsCare expendituresFinancial burdenRegional variationMedian costPatient demographicsClinical characteristicsAdult patientsBypass surgeryNortheast regionPatient characteristicsLong-term outcomes after autogenous versus synthetic lower extremity bypass in patients on hemodialysis
Arhuidese I, Hicks C, Locham S, Obeid T, Nejim B, Malas M. Long-term outcomes after autogenous versus synthetic lower extremity bypass in patients on hemodialysis. Surgery 2017, 162: 1071-1079. PMID: 28712733, DOI: 10.1016/j.surg.2017.04.026.Peer-Reviewed Original ResearchConceptsLong-term outcomesBypass operationProsthetic conduitHemodialysis patientsAutogenous conduitLimb salvageHigh-risk population of patientsEvaluate long-term outcomesCohort of hemodialysis patientsPrimary-assisted patencyFemoral-tibialType of bypassCox regression analysisLower extremity bypassPopulation of patientsUnited States Renal Data SystemHigh-risk populationPatient's life expectancyPopulation-based cohortCritical limb ischemiaPopliteal-tibial bypassSecondary patencyPrimary patencyConduit optionsPostoperative outcomes
2016
Outcomes after open infrainguinal bypass in patients with scleroderma
Arhuidese I, Malas M, Obeid T, Massada K, Khaled A, Alzahrani A, Samaha G, Reifsnyder T. Outcomes after open infrainguinal bypass in patients with scleroderma. Journal Of Vascular Surgery 2016, 64: 117-123. PMID: 27005756, DOI: 10.1016/j.jvs.2015.12.057.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAutograftsBaltimoreCritical IllnessFemaleGraft SurvivalHumansIschemiaKaplan-Meier EstimateLimb SalvageLower ExtremityMaleMiddle AgedMultivariate AnalysisPeripheral Arterial DiseaseProportional Hazards ModelsRetrospective StudiesRisk FactorsSaphenous VeinScleroderma, SystemicSeverity of Illness IndexTime FactorsTreatment OutcomeVascular GraftingVascular PatencyConceptsInfrainguinal bypass surgeryLong-term outcomesBypass surgerySystemic sclerosisGraft failureSociety for Vascular Surgery standardsScleroderma patientsArtery diseaseFollow-up durationStandard deviation ageCox regression analysisSevere peripheral arterial diseaseHistory of hypertensionLower extremity bypassCoronary artery diseaseLimb salvage rateCritical limb ischemiaPeripheral arterial diseaseDeviation ageReporting of outcomesKaplan-MeierPoor outcomeSalvage rateInfrainguinal bypassLimb ischemia
2015
Contemporary Outcomes for Open Infrainguinal Bypass in the Endovascular Era
Reifsnyder T, Arhuidese I, Hicks C, Obeid T, Massada K, Khaled A, Qazi U, Malas M. Contemporary Outcomes for Open Infrainguinal Bypass in the Endovascular Era. Annals Of Vascular Surgery 2015, 30: 52-58. PMID: 26549809, DOI: 10.1016/j.avsg.2015.10.003.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseInfrainguinal bypassLimb salvage rateCritical limb ischemiaGraft failureVein conduitSociety for Vascular Surgery standardsSalvage ratePredictors of graft failureLimb ischemiaAutogenous vein conduitPrimary-assisted patencySymptomatic peripheral arterial diseaseCohort of patientsMonitoring of high-risk groupsCox regression analysisLong-term outcomesSixty-five casesHigh-risk groupManagement of comorbiditiesLower-extremity revascularizationPrimary patencySecondary patencyRedo bypassAutogenous vein grafts
2014
Design of the Revascularization With Open Bypass vs Angioplasty and Stenting of the Lower Extremity Trial (ROBUST): A Randomized Clinical Trial
Malas M, Qazi U, Glebova N, Arhuidese I, Reifsnyder T, Black J, Perler B, Freischlag J. Design of the Revascularization With Open Bypass vs Angioplasty and Stenting of the Lower Extremity Trial (ROBUST): A Randomized Clinical Trial. JAMA Surgery 2014, 149: 1289-1295. PMID: 25353642, DOI: 10.1001/jamasurg.2014.369.Peer-Reviewed Original ResearchConceptsReduce health care costsRandomized clinical trialsOpen bypassPercutaneous transluminal angioplastyCritical limb ischemiaHospital admission costsQuality-of-life questionnaireHealth care costsAnkle brachial indexQuality of lifeImprovement of quality of lifeEXTREME trialClinical trialsTransluminal angioplastyLimb ischemiaAmputation-free survivalTransAtlantic Inter-Society ConsensusCare costsRobust trialsFemoropopliteal bypassTASC II BSecondary aimAdmission costsBrachial indexSuperficial femoral artery lesions