2023
sfkit: a web-based toolkit for secure and federated genomic analysis.
Mendelsohn S, Froelicher D, Loginov D, Bernick D, Berger B, Cho H. sfkit: a web-based toolkit for secure and federated genomic analysis. Nucleic Acids Research 2023, 51: w535-w541. PMID: 37246709, PMCID: PMC10320181, DOI: 10.1093/nar/gkad464.Peer-Reviewed Original ResearchConceptsCommand line interfaceGroup of collaboratorsCryptographic techniquesPrivacy concernsCollaborative workflowsUse casesWeb-based toolkitWeb serverComputational environmentCollaborative toolsMultiple partiesEssential taskDatasetServerPrivacyGenomic data collectionPrincipal component analysisToolkitData collectionWorkflowToolTaskComponent analysisRecent workComplexity
2021
Privacy-preserving genotype imputation in a trusted execution environment
Dokmai N, Kockan C, Zhu K, Wang X, Sahinalp S, Cho H. Privacy-preserving genotype imputation in a trusted execution environment. Cell Systems 2021, 12: 983-993.e7. PMID: 34450045, PMCID: PMC8542641, DOI: 10.1016/j.cels.2021.08.001.Peer-Reviewed Original ResearchConceptsTrusted Execution EnvironmentExecution environmentHardware-based solutionsSide-channel attacksIntel SGXEnhanced securityPrivacy concernsAnalysis servicesImputation ServerServer limitData resourcesImputation algorithmSGXServerImputation softwareGenomic data resourcesImputation accuracyGenotype imputationImputation strategiesServicesDownstream analysisScalabilityImputationEssential toolSecurity