2023
Use of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre‐study
Saini J, Garcia R, Herndon J, Erickson D, Gruber L, Bancos I. Use of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre‐study. Clinical Endocrinology 2023, 100: 203-211. PMID: 37997487, PMCID: PMC10872941, DOI: 10.1111/cen.14989.Peer-Reviewed Original ResearchConceptsDiagnosis of secondary adrenal insufficiencyOvernight metyrapone testSecondary adrenal insufficiencyCosyntropin stimulation testAdverse eventsAdrenal insufficiencyMetyrapone testPretest probabilityRetrospective study of adult patientsSingle-centre retrospective studyRetrospective single center studyDevelopment of adverse eventsStudy of adult patientsSingle center studyModerate pretest probabilityAdult patientsStimulation testCenter studyPatientsInsufficiencyDiagnosisCosyntropin
2010
Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene
Lanosa M, Willis D, Jordt S, Morris J. Role of Metabolic Activation and the TRPA1 Receptor in the Sensory Irritation Response to Styrene and Naphthalene. Toxicological Sciences 2010, 115: 589-595. PMID: 20176620, PMCID: PMC2948824, DOI: 10.1093/toxsci/kfq057.Peer-Reviewed Original ResearchConceptsSensory irritation responseIrritation responseTransient receptor potential ankyrin 1 receptorMetabolic activationFemale C57BL/6J miceCytochrome P450 activationTRPA1 receptorsC57BL/6J miceCYP450 metabolitesPlethysmographic measurementsPpm styreneSensory irritationInhibitor metyraponeP450 activationPpm naphthaleneReceptorsMiceActivationCurrent studyCritical roleResponseMetyraponeIrritationRole
2004
HPA axis activation in major depression and response to fluoxetine: a pilot study
Young E, Altemus M, Lopez J, Kocsis J, Schatzberg A, deBattista C, Zubieta J. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 2004, 29: 1198-1204. PMID: 15219644, DOI: 10.1016/j.psyneuen.2004.02.002.Peer-Reviewed Original ResearchConceptsHPA axis activationMetyrapone challengeOnset of treatmentAxis activationMajor depressionHPA axisHamilton Depression Rating Scale ratingsOpen-label treatmentHPA axis dysregulationAdrenal axis activationPremenopausal womenLabel treatmentACTH levelsHormonal contraceptivesMedical illnessACTH secretionAxis dysregulationNormal womenDepressed patientsFluoxetine respondersDepressed womenNormal subjectsAxis IGreater severityFluoxetine
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