Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation
Kumar A, Tanaka K, Schwartz M. Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation. ELife 2025, 13: rp96157. PMID: 40568958, PMCID: PMC12201949, DOI: 10.7554/elife.96157.Peer-Reviewed Original ResearchMeSH KeywordsCell AdhesionCrk-Associated Substrate ProteinFocal AdhesionsHumansPhase SeparationProtein BiosynthesisRNA, MessengerConceptsFocal adhesionsLiquid-liquid phase separationMRNA translationFocal adhesion protein p130CasIntegrin-mediated focal adhesionsFocal adhesion proteinsRNA-binding proteinsMessage translationAdhesion dynamicsP130CasAdhesion proteinsBinding proteinRegulatory mechanismsConcentrations of fibronectinCell behaviorPlate cellsSenescent cellsMRNAPhoto-inductionProteinCytoplasmCellsQuiescent stateMultiple componentsTranslationMineralocorticoid receptor phase separation modulates cardiac preservation
Lei I, Sicim H, Gao W, Huang W, Noly P, Pergande M, Wilson M, Lee A, Liu L, Abou El Ela A, Jiang M, Saddoughi S, Pober J, Platt J, Cascalho M, Pagani F, Chen Y, Pitt B, Wang Z, Mortensen R, Ge Y, Tang P. Mineralocorticoid receptor phase separation modulates cardiac preservation. Nature Cardiovascular Research 2025, 4: 710-726. PMID: 40389663, PMCID: PMC12239668, DOI: 10.1038/s44161-025-00653-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Cycle ProteinsCold IschemiaHeart TransplantationHistone Deacetylase 1HumansKidneyLiverLungMaleMiceMice, Inbred C57BLMineralocorticoid Receptor AntagonistsMyocytes, CardiacNuclear ProteinsOrgan PreservationPhase SeparationReceptors, MineralocorticoidTissue DonorsTranscription FactorsConceptsMineralocorticoid receptorDonor heartsHistone deacetylase 1Bromodomain-containing 4Gold standard treatmentEnd-stage heart failureCold ischemic timeShortage of donor heartsExpressed MRDonor cardiomyocytesHuman donor heartsHeart transplantationStandard treatmentIschemic timeHeart failureCardiac preservationSolid organsPharmacological inhibitionCold preservationPreserving biologyHeart
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