2022
Rational engineering of industrial S. cerevisiae: towards xylitol production from sugarcane straw
de Mello FDSB, Maneira C, Suarez FUL, Nagamatsu S, Vargas B, Vieira C, Secches T, Coradini ALV, de Carvalho Silvello M, Goldbeck R, Pereira GAG, Teixeira GS. Rational engineering of industrial S. cerevisiae: towards xylitol production from sugarcane straw. Journal Of Genetic Engineering And Biotechnology 2022, 20: 80. PMID: 35612634, PMCID: PMC9133290, DOI: 10.1186/s43141-022-00359-8.Peer-Reviewed Original ResearchXylose reductaseS. cerevisiaeBrazilian bioethanol industryIndustrial S. cerevisiaeMajor yeastGenomic integrationNucleotide sequenceCRISPR editingGenetic engineeringInhibitor toleranceXylitol productionIndustrial strainsRobust chassisHigh economic valueNADPH availabilityNADPH cofactorAvailable cofactorsRational engineeringRedox environmentGenetic backgroundXylitol titerHemicellulosic materialLaboratory strainsFermentation performanceCerevisiae
2009
Early onset senescence occurs when fibroblasts lack the glutamate–cysteine ligase modifier subunit
Chen Y, Johansson E, Fan Y, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP. Early onset senescence occurs when fibroblasts lack the glutamate–cysteine ligase modifier subunit. Free Radical Biology And Medicine 2009, 47: 410-418. PMID: 19427898, PMCID: PMC2773044, DOI: 10.1016/j.freeradbiomed.2009.05.003.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsbeta-GalactosidaseCell Culture TechniquesCell CycleCell Growth ProcessesCellular SenescenceCyclin-Dependent Kinase Inhibitor p21DNA DamageFemaleFetusFibroblastsFree Radical ScavengersGlutamate-Cysteine LigaseGlutathioneMiceMice, Inbred C57BLMice, KnockoutPregnancyProtein SubunitsReactive Oxygen SpeciesTumor Suppressor Protein p53ConceptsGlutamate-cysteine ligasePremature senescenceCellular redox environmentCellular antioxidant glutathionePrimary murine fibroblastsSenescence-associated beta-galactosidase activityCell cycle arrestInduction of p53Beta-galactosidase activityPrevents premature senescenceCatalytic subunitCellular senescenceGrowth arrestGlutamate cysteine ligase modifierModifier subunitP21 proteinPhysiological roleSenescenceDNA damageRedox environmentCycle arrestMurine fibroblastsGSH synthesisN-acetylcysteine increasesPrimary cells
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