2018
Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome
Yu X, Teng XL, Wang F, Zheng Y, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li HB, Su B, Lu L, Liu Z, Sun SC, Zou Q. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. Journal Of Experimental Medicine 2018, 215: 2463-2476. PMID: 30115741, PMCID: PMC6122976, DOI: 10.1084/jem.20180397.Peer-Reviewed Original ResearchConceptsCell metabolismPhosphatase catalytic subunitRapamycin complex 1Component raptorRegulatory T Cell StabilityCatalytic subunitMetabolic programsMechanistic targetPivotal regulatorSignaling mechanismTRAF3IP3Metabolic regulatorMetabolic fitnessCell functionRegulatorLysosomesMetabolismT reg cell functionCell stabilityPP2AcComplexes 1RaptorsSubunitsDeletionStrong antitumor T-cell responses
2010
The Association of AMPK with ULK1 Regulates Autophagy
Lee J, Park S, Takahashi Y, Wang H. The Association of AMPK with ULK1 Regulates Autophagy. PLOS ONE 2010, 5: e15394. PMID: 21072212, PMCID: PMC2972217, DOI: 10.1371/journal.pone.0015394.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesAnimalsAutophagyAutophagy-Related Protein-1 HomologBinding SitesCell LineCell Line, TumorCells, CulturedHEK293 CellsHumansImmunoblottingImmunoprecipitationIntracellular Signaling Peptides and ProteinsMechanistic Target of Rapamycin Complex 1MiceMice, KnockoutMicroscopy, FluorescenceMultiprotein ComplexesMutationPhosphorylationProtein BindingProtein Serine-Threonine KinasesProtein SubunitsProteinsRegulatory-Associated Protein of mTORRNA InterferenceTOR Serine-Threonine KinasesTransfectionConceptsEffects of mTORAMPK phosphorylation sitesSerine/threonine kinase ULK1Central energy sensorPhosphorylation of RaptorActivation of AMPKTSC2-deficient cellsInitiation of autophagyIntracellular bulk degradation processPhosphorylation sitesKinase ULK1Inhibitory effectPS domainsEnergy sensorMTOR inactivationEnvironmental stressAMPKMolecular mechanismsMTOR kinaseULK1RaptorsAutophagy inductionAutophagyAICARPhosphorylation
2006
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
Liu L, Li F, Cardelli J, Martin K, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 2006, 25: 7029-7040. PMID: 16715128, DOI: 10.1038/sj.onc.1209691.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCattleCell Cycle ProteinsCell LineCell MovementCytoprotectionDown-RegulationEnzyme ActivationHumansInsulin-Like Growth Factor IMicePhosphoproteinsPhosphorylationProtein KinasesRibosomal Protein S6 Kinases, 70-kDaSerumSignal TransductionSirolimusTOR Serine-Threonine KinasesTranscription FactorsConceptsCell motilityRNA interferenceEukaryotic initiation factor 4EDownregulation of RaptorType I insulin-like growth factorMTOR kinase activityInitiation factor 4ES6 kinase 1Rapamycin inhibitionTumor cell motilityResistant mutantsSuppression of mTORP70 S6K1Kinase activityKinase 1S6K1Mammalian targetRapamycinProtein 1Effect of rapamycinConsequence of inhibitionCell linesMutantsRaptorsMotility
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply