Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors
Mastorakos P, Zhang C, Song E, Kim Y, Park H, Berry S, Choi W, Hanes J, Suk J. Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors. Journal Of Controlled Release 2017, 262: 37-46. PMID: 28694032, PMCID: PMC5824426, DOI: 10.1016/j.jconrel.2017.07.009.Peer-Reviewed Original ResearchConceptsMalignant brain tumorsBrain tumorsOrthotopic rat brain tumorsPrimary brain tumorsRat brain tumorsOrthotopic brain tumor modelHealthy brain parenchymaBrain tumor modelBrain tumor tissueTransgene expressionWidespread transgene expressionBrain parenchymaClinical developmentTissues ex vivoGene therapy approachesTumor edgeTumor tissueTumor modelTumorsEx vivoCancer cellsTherapy approachesWidespread deliveryRatsTumor core
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