2017
Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors
Mastorakos P, Zhang C, Song E, Kim Y, Park H, Berry S, Choi W, Hanes J, Suk J. Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors. Journal Of Controlled Release 2017, 262: 37-46. PMID: 28694032, PMCID: PMC5824426, DOI: 10.1016/j.jconrel.2017.07.009.Peer-Reviewed Original ResearchConceptsMalignant brain tumorsBrain tumorsOrthotopic rat brain tumorsPrimary brain tumorsRat brain tumorsOrthotopic brain tumor modelHealthy brain parenchymaBrain tumor modelBrain tumor tissueTransgene expressionWidespread transgene expressionBrain parenchymaClinical developmentTissues ex vivoGene therapy approachesTumor edgeTumor tissueTumor modelTumorsEx vivoCancer cellsTherapy approachesWidespread deliveryRatsTumor core
2014
Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses
Roberts N, Zhang L, Janku F, Collins A, Bai R, Staedtke V, Rusk A, Tung D, Miller M, Roix J, Khanna K, Murthy R, Benjamin R, Helgason T, Szvalb A, Bird J, Roy-Chowdhuri S, Zhang H, Qiao Y, Karim B, McDaniel J, Elpiner A, Sahora A, Lachowicz J, Phillips B, Turner A, Klein M, Post G, Diaz L, Riggins G, Papadopoulos N, Kinzler K, Vogelstein B, Bettegowda C, Huso D, Varterasian M, Saha S, Zhou S. Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Science Translational Medicine 2014, 6: 249ra111. PMID: 25122639, PMCID: PMC4399712, DOI: 10.1126/scitranslmed.3008982.Peer-Reviewed Original ResearchConceptsC. novyi-NT sporesIntratumoral injectionHuman patientsCanine tumorsFurther clinical trialsOrthotopic brain tumor modelC. novyi-NTBrain tumor modelClostridium novyi-NT sporesSpontaneous solid tumorsCommon toxicitiesObjective responsePartial responseAdvanced leiomyosarcomaAntitumor responseClinical trialsHeterogeneous genetic backgroundHuman trialsSolid tumorsBacterial infectionsNeoplastic tissueTumor modelTumorsTherapeutic agentsPatients
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