2013
Gaucher Disease and Malignancy: A Model for Cancer Pathogenesis in an Inborn Error of Metabolism
Mistry PK, Taddei T, vom Dahl S, Rosenbloom BE. Gaucher Disease and Malignancy: A Model for Cancer Pathogenesis in an Inborn Error of Metabolism. Critical Reviews™ In Oncogenesis 2013, 18: 235-246. PMID: 23510066, PMCID: PMC4437216, DOI: 10.1615/critrevoncog.2013006145.BooksConceptsEnzyme replacement therapyCancer riskGaucher diseaseMacrophage-targeted enzyme replacement therapyChronic B-cell stimulationCancer pathogenesisType 1 Gaucher diseaseSubset of patientsT cell dysfunctionNon-hematological malignanciesOverall cancer riskRisk of cancerNovel therapeutic targetPolarization of macrophagesDeterminant of malignancyB cell stimulationAccumulation of glucosylceramideEndoplasmic reticulum stressLysosomal storage disorderImmune dysregulationChronic inflammationIncreased prevalenceReplacement therapyMultiple myelomaConsecutive cancers
2010
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions
Maul RW, Saribasak H, Martomo SA, McClure RL, Yang W, Vaisman A, Gramlich HS, Schatz DG, Woodgate R, Wilson DM, Gearhart PJ. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nature Immunology 2010, 12: 70-76. PMID: 21151102, PMCID: PMC3653439, DOI: 10.1038/ni.1970.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigenic VariationB-LymphocytesCells, CulturedCytidine DeaminaseDNA-(Apurinic or Apyrimidinic Site) LyaseImmunoglobulin Class SwitchingImmunoglobulin Variable RegionInterleukin-4LipopolysaccharidesLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutModels, ChemicalSpleenUracilUracil-DNA Glycosidase
1989
Immunological effects of HIV-1 infection on the humoral response to malaria in an African population.
Wabwire-Mangen F, Shiff C, Vlahov D, Kline R, Serwadda D, Sewankambo N, Mugerwa R, Quinn T. Immunological effects of HIV-1 infection on the humoral response to malaria in an African population. American Journal Of Tropical Medicine And Hygiene 1989, 41: 504-11. PMID: 2683820, DOI: 10.4269/ajtmh.1989.41.504.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAnimalsAntibodies, ProtozoanAntigens, ProtozoanAntigens, SurfaceCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHIV SeropositivityHIV-1HumansMalariaMaleMiddle AgedPlasmodiumPlasmodium falciparumPlasmodium malariaeProtozoan ProteinsUgandaConceptsHIV-1 infectionTrauma patientsClinical AIDSSeronegative patientsAntibody levelsHIV-1HIV-1-seronegative patientsHIV-1 seropositive patientsPolyclonal B cell activationCross-sectional studyHigh malaria transmissionB cell stimulationB cell activationSeropositive patientsImmunodeficiency syndromeMalaria antibodiesHumoral responseImmunological effectsSerological responseStudy groupPatientsCell activationMalaria transmissionControl populationLess antibody
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