1999
What Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy Revisited
Preisig P. What Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy Revisited. Experimental Nephrology 1999, 7: 273-283. PMID: 10450014, DOI: 10.1159/000020614.Peer-Reviewed Original ResearchConceptsCell cycle-dependent mechanismCell cycle-independent mechanismsCell cycle processRegulation of processesRenal hypertrophyProtein degradationChronic potassium deficiencyCompensatory renal growthChronic metabolic acidosisDevelopment of hypertrophyCompensatory renal hypertrophyPotassium deficiencyDiabetes mellitusMetabolic acidosisLysosomal enzymesRenal growthCell sizeHypertrophyCell numberInitial eventProtein feedingRegulationVivo studiesCell culture studiesCycle process
1997
A syndrome of congenital hyperinsulinism and hyperammonemia
Weinzimer S, Stanley C, Berry G, Yudkoff M, Tuchman M, Thornton P. A syndrome of congenital hyperinsulinism and hyperammonemia. The Journal Of Pediatrics 1997, 130: 661-664. PMID: 9108870, DOI: 10.1016/s0022-3476(97)70256-7.Peer-Reviewed Original ResearchConceptsCongenital hyperinsulinismLarge glycemic responseAcid levelsFree fatty acid levelsUrea cycle enzyme defectsElevated insulin levelsDiagnosis of hyperinsulinismUrinary amino acidsOrotic acid levelsUrinary orotic acid levelsAdministration of glucagonFatty acid levelsAutosomal recessive variantInsulin levelsBenzoate therapyProtein restrictionInsulin secretionUnusual syndromeUrinary organic acidsHyperammonemic disordersGlycemic responseHyperinsulinismPatientsProtein feedingRecessive variants
1991
Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy.
Preisig PA, Alpern RJ. Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy. Journal Of General Physiology 1991, 97: 195-217. PMID: 1849958, PMCID: PMC2216475, DOI: 10.1085/jgp.97.2.195.Peer-Reviewed Original ResearchConceptsHyperfiltration groupChronic hyperfiltrationNa/H antiporterKidney weightCell hypertrophyHigher glomerular filtration rateNa/H antiporter activityH antiporterGlomerular filtration rateVivo microperfused rat proximal tubuleCell pHRat proximal tubuleSymporter activityFiltration rateProximal tubulesUltrafiltrate-like solutionHyperfiltrationSteady-state cell pHProtein feedingPeritubular perfusateDietary proteinParallel increaseUninephrectomyHypertrophyCell acidification
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