2022
Whole-Exome Sequencing of Germline Variants in Non-BRCA Families with Hereditary Breast Cancer
Liu Y, Helgadottir HT, Kharaziha P, Choi J, López-Giráldez F, Mane SM, Höiom V, Juhlin CC, Larsson C, Bajalica-Lagercrantz S. Whole-Exome Sequencing of Germline Variants in Non-BRCA Families with Hereditary Breast Cancer. Biomedicines 2022, 10: 1004. PMID: 35625741, PMCID: PMC9138793, DOI: 10.3390/biomedicines10051004.Peer-Reviewed Original ResearchHereditary breast cancerBreast cancerWhole-exome sequencingBreast cancer susceptibilityHereditary cancer-related genesHigh-risk cancer genesFamilial casesCancer susceptibilityAutosomal dominant inheritance patternDominant inheritance patternPrevalent malignancyFamily historyCancer-related genesCancer-related pathwaysPathogenic variantsProtein expression analysisGermline variantsCancerFunction variantsExome sequencingRecurrent genesRisk variantsInheritance patternMinor allele frequencyExonic variants
2014
NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia
D’Amico A, Scuderi S, Maugeri G, Cavallaro S, Drago F, D’Agata V. NAP Reduces Murine Microvascular Endothelial Cells Proliferation Induced by Hyperglycemia. Journal Of Molecular Neuroscience 2014, 54: 405-413. PMID: 24874579, DOI: 10.1007/s12031-014-0335-2.Peer-Reviewed Original ResearchConceptsProtein kinase/extracellular signal-regulated protein kinaseExtracellular signal-regulated protein kinaseMitogen-activated protein kinase/extracellular signal-regulated protein kinaseSignal-regulated protein kinaseKinase/Akt pathwayEndothelial cell proliferationPhosphatidylinositol-3-kinase/Akt pathwayCell proliferationProtein expression analysisProtein kinaseExpression analysisBiological roleAkt pathwayPhosphorylation levelsTime-dependent mannerHigh glucoseMurine microvascular endothelial cellsMicrovascular endothelial cell proliferationMicrovascular endothelial cellsEndothelial cellsProliferationMTT assayCellsMarkers of Epithelial to Mesenchymal Transition in Association with Survival in Head and Neck Squamous Cell Carcinoma (HNSCC)
Pectasides E, Rampias T, Sasaki C, Perisanidis C, Kouloulias V, Burtness B, Zaramboukas T, Rimm D, Fountzilas G, Psyrri A. Markers of Epithelial to Mesenchymal Transition in Association with Survival in Head and Neck Squamous Cell Carcinoma (HNSCC). PLOS ONE 2014, 9: e94273. PMID: 24722213, PMCID: PMC3983114, DOI: 10.1371/journal.pone.0094273.Peer-Reviewed Original ResearchMeSH KeywordsAutomationBiomarkers, TumorCarcinoma, Squamous CellCohort StudiesEpithelial-Mesenchymal TransitionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedImmunohistochemistryKaplan-Meier EstimateMaleMultivariate AnalysisNeoplasm MetastasisPhenotypePrognosisProportional Hazards ModelsSquamous Cell Carcinoma of Head and NeckTreatment OutcomeConceptsProgression-free survivalSquamous cell carcinomaOverall survivalCell carcinomaE-cadherinPrimary squamous cell carcinomaNeck squamous cell carcinomaHigh-risk HNSCCKaplan-Meier analysisNovel therapeutic approachesMesenchymal transition phenotypeHigh metastatic potentialLow E-cadherinImproved OSInferior OSIndependent predictorsPoor prognosisCarcinoma prognosisClinicopathological parametersInclusion criteriaTherapeutic approachesTransition phenotypeMetastatic potentialMesenchymal transitionProtein expression analysis
2005
Quantitative insitu cancer proteomics: molecular pathology comes of age with automated tissue microarray analysis
Dolled-Filhart MP, Rimm DL, Stroobant P. Quantitative insitu cancer proteomics: molecular pathology comes of age with automated tissue microarray analysis. Personalized Medicine 2005, 2: 291-300. PMID: 29788575, DOI: 10.2217/17410541.2.4.291.Peer-Reviewed Original ResearchProtein expression analysisExpression analysisProtein expressionPotential future therapeutic developmentsHigh-throughput methodAutomated Quantitative AnalysisMicroarray analysisTarget discoverySitu protein expressionTissue microarray analysisFluorescence microscopyFuture therapeutic developmentMicroarrayTissue microarrayNew targetsDynamic rangeDiscovery toolMolecular pathologyTherapeutic developmentUnparalleled opportunityUnique roleMicroscope slidesTumor samplesExpressionNovel prognostic marker
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