2025
DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures
Leelatian N, Singh C, Bouffard R, Sundaram R, Diggins K, Sullivan W, Paradkar S, Omay Z, Mobley B, Gueble S, Vasquez J, Bindra R. DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures. Neuro-Oncology 2025, noaf199. PMID: 40887772, DOI: 10.1093/neuonc/noaf199.Peer-Reviewed Original ResearchDNA damage responseLow-grade gliomasGene expression patternsGene expressionDiffuse gliomasImaging Mass CytometryPoor survivalHigher abundanceSingle-cell heterogeneityAssociated with poor survivalClinical assessmentSingle-cell protein analysisDNA methylation profilesGlobal DNA methylation profilesIDH mutation statusDNA damage response defectsProliferative tumor cellsNovel treatment strategiesOutcome of gliomaEffector expressionMGMT statusMutation statusTumor levelsActive area of investigationMethylation profiles
2012
Neurosurgical Approach
Moliterno JA, Patel TR, Piepmeier JM. Neurosurgical Approach. The Cancer Journal 2012, 18: 20-25. PMID: 22290253, DOI: 10.1097/ppo.0b013e3183243f6e3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingTumor cellsResonance imagingAggressive surgical resectionAggressive tumor removalFunctional brain tissueFrequency of seizuresExtent of resectionGoal of surgeryInfiltrative tumor cellsPreferred initial stepFunctional magnetic resonance imagingProliferative tumor cellsAdjuvant therapyAggressive resectionSurgical resectionTumors recurCritical cortical regionsNeurologic impairmentTumor burdenProspective studyTumor resectionTumor removalInfiltrative tumorsMalignant gliomas
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