DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures
Leelatian N, Singh C, Bouffard R, Sundaram R, Diggins K, Sullivan W, Paradkar S, Omay Z, Mobley B, Gueble S, Vasquez J, Bindra R. DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures. Neuro-Oncology 2025, noaf199. PMID: 40887772, DOI: 10.1093/neuonc/noaf199.Peer-Reviewed Original ResearchDNA damage responseLow-grade gliomasGene expression patternsGene expressionDiffuse gliomasImaging Mass CytometryPoor survivalHigher abundanceSingle-cell heterogeneityAssociated with poor survivalClinical assessmentSingle-cell protein analysisDNA methylation profilesGlobal DNA methylation profilesIDH mutation statusDNA damage response defectsProliferative tumor cellsNovel treatment strategiesOutcome of gliomaEffector expressionMGMT statusMutation statusTumor levelsActive area of investigationMethylation profiles
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