2024
Single-Cell Analysis Reveals a Subset of High IL-12p40-Secreting Dendritic Cells within Mouse Bone Marrow-Derived Macrophages Differentiated with M-CSF.
Bridges K, Pizzurro G, Khunte M, Chen M, Salvador Rocha E, Alexander A, Bass V, Kellman L, Baskaran J, Miller-Jensen K. Single-Cell Analysis Reveals a Subset of High IL-12p40-Secreting Dendritic Cells within Mouse Bone Marrow-Derived Macrophages Differentiated with M-CSF. The Journal Of Immunology 2024, 212: 1357-1365. PMID: 38416039, DOI: 10.4049/jimmunol.2300431.Peer-Reviewed Original ResearchBone marrow-derived macrophagesDendritic cellsCell-to-cell heterogeneitySingle-cell RNA sequencing dataRNA sequencing dataSingle-cell analysisIL-12p40Sequence dataExpression of IL12BInnate immune functionProduction of IL-12Bone marrow-derived macrophage culturesMurine bone marrow-derived macrophagesSurface marker expressionAcute inflammatory responseMarrow-derived macrophagesGene encoding IL-12p40Secretion assayIL12B expressionReporter miceDC lineageIL-12GenesProinflammatory cytokinesM-CSF
2019
ATIM-18. SURVIVAL OF SUBJECTS WITH RECURRENT GLIOBLASTOMA RECEIVING INTRA-TUMORAL ADMINISTRATION OF IL-12 MANAGED WITH LOW-DOSE DEXAMETHASONE
Lukas R, Chiocca E, Kurz S, Yu J, Landolfi J, Rao G, Buck J, Demars N, Smith A, Miao J, Zhou J, Wang Y, Gelb A, Cooper L. ATIM-18. SURVIVAL OF SUBJECTS WITH RECURRENT GLIOBLASTOMA RECEIVING INTRA-TUMORAL ADMINISTRATION OF IL-12 MANAGED WITH LOW-DOSE DEXAMETHASONE. Neuro-Oncology 2019, 21: vi5-vi5. PMCID: PMC6847372, DOI: 10.1093/neuonc/noz175.018.Peer-Reviewed Original ResearchLow-dose dexamethasoneIL-12IFN-gIntratumoral injection of AdOngoing phase 1Low-dose corticosteroidsIntra-tumoral administrationProduction of IL-12Drug-related toxicityInjection of AdRecombinant IL-12Induce IL-12Overall survivalIntratumoral injectionDose-relatedDrug-related deathsGene therapyHistorical controlsAnticipated survivalSubject characteristicsSurvival dataSurvivalBiomarker studiesBiomarker analysisBiomarkers
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