Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case–control sets from the European Prospective Investigation into Cancer and Nutrition
Grenville Z, Noor U, Rinaldi S, Gunter M, Ferrari P, Agnoli C, Amiano P, Catalano A, Chirlaque M, Christakoudi S, Guevara M, Johansson M, Kaaks R, Katzke V, Masala G, Olsen A, Papier K, Sánchez M, Schulze M, Tjønneland A, Tong T, Tumino R, Weiderpass E, Zamora‐Ros R, Key T, Smith‐Byrne K, Schmidt J, Travis R. Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case–control sets from the European Prospective Investigation into Cancer and Nutrition. International Journal Of Cancer 2024, 156: 943-952. PMID: 39378119, PMCID: PMC11701393, DOI: 10.1002/ijc.35208.Peer-Reviewed Original ResearchConceptsAssociated with advanced prostate cancerAdvanced prostate cancerProstate cancerEuropean Prospective InvestigationMetabolite patternsAssociated with prostate cancer deathMultivariable-adjusted conditional logistic regressionProspective InvestigationPresence of prostate cancerHigh-grade prostate cancerProstate cancer overallProstate cancer riskProstate cancer deathAdvanced-stage diseaseCancer and NutritionFollow-up timeYear of blood collectionProstate cancer diagnosisMetabolite profile changesCase-control pairsConditional logistic regressionCase-control settingBlood metabolomeCancer overallFollow-up
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