2021
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)
Chen PH, Hu Z, An E, Okeke I, Zheng S, Luo X, Gong A, Jaime-Figueroa S, Crews CM. Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs). ACS Chemical Biology 2021, 16: 2808-2815. PMID: 34780684, PMCID: PMC10437008, DOI: 10.1021/acschembio.1c00693.Peer-Reviewed Original ResearchConceptsSer/Thr phosphataseChemical biology approachPP2A holoenzymeProtein dephosphorylationBiology approachProtein substratesTranscriptional activationProtein phosphorylationCatalytic subunitCell biologyReporter geneProtein activityRetinoblastoma proteinOff-target effectsCritical proteinsDephosphorylationTernary complexPhosphorylationKinase inhibitorsFOXO3aPROTACsProteinChimerasPhosphataseDrug resistance
1999
The RCN1‐encoded A subunit of protein phosphatase 2A increases phosphatase activity in vivo
Deruère J, Jackson K, Garbers C, Söll D, DeLong A. The RCN1‐encoded A subunit of protein phosphatase 2A increases phosphatase activity in vivo. The Plant Journal 1999, 20: 389-399. PMID: 10607292, DOI: 10.1046/j.1365-313x.1999.00607.x.Peer-Reviewed Original ResearchConceptsProtein phosphatase 2AMutant seedlingsOrgan elongationPhosphatase 2ARegulatory subunitSerine/threonine-specific protein phosphataseT-DNA insertion mutationPhosphatase inhibitor okadaic acidCatalytic C subunitWild-type seedlingsDistinct regulatory subunitsLateral root primordiaInhibitor okadaic acidCell elongation responseLight-grown seedlingsCatalytic subunit expressionRcn1 mutationPP2A holoenzymeShoot meristemProtein phosphataseRCN1 geneC subunitLeaf primordiaElongation assaysPositive regulator
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