Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19
Allard-Chamard H, Kaneko N, Bertocchi A, Sun N, Boucau J, Kuo H, Farmer J, Perugino C, Mahajan V, Murphy S, Premo K, Diefenbach T, Ghebremichael M, Yuen G, Kotta A, Akman Z, Lichterfeld M, Walker B, Yu X, Moriyama M, Maehara T, Nakamura S, Stone J, Padera R, Pillai S. Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19. Cell Reports 2023, 42: 112630. PMID: 37300833, PMCID: PMC10227203, DOI: 10.1016/j.celrep.2023.112630.Peer-Reviewed Original ResearchConceptsB cell subsetsB-cell depletionIgG4-related diseaseB cellsSevere COVID-19Autoimmune diseasesDouble-negative B cellsPathogenic B cell subsetsCD4<sup>+</sup> T cellsTherapeutic B cell depletionAutoimmune fibrotic diseasesT cellsTissue inflammationInflamed tissuesLung lesionsImmunoglobulin DFibrosisFibrotic diseasesInflammationLesionsDiseaseCOVID-19DN3SubsetsDisease lesions
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