2023
Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19
Allard-Chamard H, Kaneko N, Bertocchi A, Sun N, Boucau J, Kuo H, Farmer J, Perugino C, Mahajan V, Murphy S, Premo K, Diefenbach T, Ghebremichael M, Yuen G, Kotta A, Akman Z, Lichterfeld M, Walker B, Yu X, Moriyama M, Maehara T, Nakamura S, Stone J, Padera R, Pillai S. Extrafollicular IgD−CD27−CXCR5−CD11c− DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19. Cell Reports 2023, 42: 112630. PMID: 37300833, PMCID: PMC10227203, DOI: 10.1016/j.celrep.2023.112630.Peer-Reviewed Original ResearchConceptsB cell subsetsB-cell depletionIgG4-related diseaseB cellsSevere COVID-19Autoimmune diseasesDouble-negative B cellsPathogenic B cell subsetsCD4<sup>+</sup> T cellsTherapeutic B cell depletionAutoimmune fibrotic diseasesT cellsTissue inflammationInflamed tissuesLung lesionsImmunoglobulin DFibrosisFibrotic diseasesInflammationLesionsDiseaseCOVID-19DN3SubsetsDisease lesions
2007
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
Hu CY, Rodriguez-Pinto D, Du W, Ahuja A, Henegariu O, Wong FS, Shlomchik MJ, Wen L. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. Journal Of Clinical Investigation 2007, 117: 3857-3867. PMID: 18060033, PMCID: PMC2096456, DOI: 10.1172/jci32405.Peer-Reviewed Original ResearchConceptsB-cell depletionCell depletionB cellsNOD miceTherapeutic B cell depletionTransgenic NOD miceRegulatory B cellsLong-term remissionExpansion of TregsOnset of diabetesType 1 diabetesReverse diabetesClinical efficacyDiabetic miceAutoimmune diseasesFrank hyperglycemiaAntigen presentationT cellsHuman CD20DiabetesTherapeutic actionMiceClinical hyperglycemiaDiseasePotential mechanisms
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