2022
The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands
Wang W, Pyle AM. The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Molecular Cell 2022, 82: 4131-4144.e6. PMID: 36272408, PMCID: PMC9707737, DOI: 10.1016/j.molcel.2022.09.029.Peer-Reviewed Original ResearchConceptsRNA moleculesRNA ligandsHigh-resolution cryo-EM structuresCryo-EM structureDouble-stranded RNARIG-I receptorInduction of autoimmunityViral RNA moleculesAutoinhibited conformationInnate immune receptorsHost RNARelated RNAProtein foldsMolecular basisUnique molecular featuresHigh-affinity conformationAntiviral sensingHost cellsRNA virusesRNA releaseImmune receptorsRNAViral RNAExquisite selectivityMolecular features
2021
Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation
Wu K, Wu H, Lyu W, Kim Y, Furdui CM, Anderson KS, Koleske AJ. Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation. Journal Of Biological Chemistry 2021, 297: 100883. PMID: 34144039, PMCID: PMC8259415, DOI: 10.1016/j.jbc.2021.100883.Peer-Reviewed Original ResearchConceptsAbl family kinasesFamily kinasesPlatelet-derived growth factor receptor betaGrowth factor receptor betaAbl familySrc homology 2 domainSrc homology 3 domainDiverse cellular stimuliPost-translational modificationsN-terminal halfNonreceptor tyrosine kinaseMultiple novel sitesAutoinhibited conformationSrc homologyCytoskeleton organizationCytoplasmic domainCellular stimuliKinase domainGrowth factor receptorReceptor betaKinase activityMolecular mechanismsTyrosine kinaseDirect bindingKinase
2005
Jak3 Kinase Domain Crystal Structures and Implications for Jak-Specific Drug Design.
Boggon T. Jak3 Kinase Domain Crystal Structures and Implications for Jak-Specific Drug Design. Blood 2005, 106: 69. DOI: 10.1182/blood.v106.11.69.69.Peer-Reviewed Original ResearchJAK3 kinase domainKinase domainDomain crystal structureResolution co-crystal structureJAK kinase family membersTyrosine kinaseLatent transcription factorsNon-receptor tyrosine kinaseActivation of transcriptionReceptor cytoplasmic tailKinase family membersRapid tyrosine phosphorylationThree-dimensional structural dataJAK-specific inhibitorDrug designTyrosine kinase activityFurther crystal structuresAutoinhibited conformationCo-crystal structureJAK activityConformational plasticityCytoplasmic tailTranscription factorsTranscription (STAT) proteinsGrowth factor receptor
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