2021
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A2 is unrestrained
D'Agostino I, Tacconelli S, Bruno A, Contursi A, Mucci L, Hu X, Xie Y, Chakraborty R, Jain K, Sacco A, Zucchelli M, Landolfi R, Dovizio M, Falcone L, Ballerini P, Hwa J, Patrignani P. Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A2 is unrestrained. Pharmacological Research 2021, 170: 105744. PMID: 34182131, DOI: 10.1016/j.phrs.2021.105744.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntifibrotic AgentsAntihypertensive AgentsAspirinBiomarkersBlood PlateletsBlood PressureCardiomyopathiesCase-Control StudiesCells, CulturedDisease Models, AnimalEssential HypertensionFemaleFibrosisHumansMaleMice, Inbred C57BLMice, KnockoutMiddle AgedMyocytes, CardiacMyofibroblastsPlatelet Aggregation InhibitorsReceptors, EpoprostenolReceptors, ThromboxaneThromboxane A2ConceptsProfibrotic gene expressionEnhanced blood pressureBlood pressureCardiac fibrosisPlatelet TXAHypertensive patientsOverload-induced cardiac fibrosisLow-dose aspirin administrationEarly cardiac fibrosisPlatelet-derived thromboxaneLow-dose aspirinEssential hypertensive patientsEssential hypertension patientsHigh-salt dietSalt-sensitive hypertensionCardiac collagen depositionNumber of myofibroblastsSelective inhibitionGene expressionPrevents hypertensionTP overexpressionUrinary TXMAspirin administrationHypertensive miceAspirin treatment
1999
Prostanoids
Davis K, Fabian T, Croce M, Proctor K. Prostanoids. Journal Of Trauma And Acute Care Surgery 1999, 46: 824-832.. PMID: 10338399, DOI: 10.1097/00005373-199905000-00010.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressurePulmonary capillary leakEnd-expiratory pressurePMN infiltrationPulmonary failureRight thoraxSecondary injuryInflammatory responseCapillary leakPlatelet-derived thromboxaneBlunt chest traumaHours of injurySecondary inflammatory responseBronchoalveolar lavage proteinSerial bronchoalveolar lavagesCyclooxygenase inhibitor indomethacinUnilateral pulmonary contusionPulmonary contusionChest traumaProfound hypoxemiaSham injuryBlunt injuryLeft lungBronchoalveolar lavageNeutrophil content
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