Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance
Ogbunugafor C, Wylie C, Diakite I, Weinreich D, Hartl D. Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance. PLOS Computational Biology 2016, 12: e1004710. PMID: 26808374, PMCID: PMC4726534, DOI: 10.1371/journal.pcbi.1004710.Peer-Reviewed Original ResearchConceptsEvolution of drug resistanceAdaptive landscapeMinimal inhibitory concentrationMutational effectsPatterns of epistasisDrug resistanceDihydrofolate reductaseLandscape topographyDrug environmentEmpirical adaptive landscapesEvolutionary outcomesEvolutionary dynamicsOutcome of drug treatmentInhibitory concentrationPlasmodium falciparum dihydrofolate reductaseMutationsModels of drug resistanceCross-resistance
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