2019
Genetic Background Modifies the Topography of a Fitness Landscape, Influencing the Dynamics of Adaptive Evolution
Ogbunugafor C, Eppstein M. Genetic Background Modifies the Topography of a Fitness Landscape, Influencing the Dynamics of Adaptive Evolution. IEEE Access 2019, 7: 113675-113683. DOI: 10.1109/access.2019.2935911.Peer-Reviewed Original ResearchDynamics of adaptive evolutionAdaptive evolutionGenetic variabilityTopography of fitness landscapesFitness landscape topographyFitness landscapeApplications of evolutionary biologyEmpirical fitness landscapesEvolution of drug resistanceGenetic contextBackground modifiersDirection of evolutionEvolutionary biologyGenetic backgroundLandscape topographyDrug resistanceGenetically-modified organismsLociLandscapeBiological evolutionProteinEvolution
2016
Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance
Ogbunugafor C, Wylie C, Diakite I, Weinreich D, Hartl D. Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance. PLOS Computational Biology 2016, 12: e1004710. PMID: 26808374, PMCID: PMC4726534, DOI: 10.1371/journal.pcbi.1004710.Peer-Reviewed Original ResearchConceptsEvolution of drug resistanceAdaptive landscapeMinimal inhibitory concentrationMutational effectsPatterns of epistasisDrug resistanceDihydrofolate reductaseLandscape topographyDrug environmentEmpirical adaptive landscapesEvolutionary outcomesEvolutionary dynamicsOutcome of drug treatmentInhibitory concentrationPlasmodium falciparum dihydrofolate reductaseMutationsModels of drug resistanceCross-resistance
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