2017
Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM
Hwang JJ, Jiang L, Hamza M, Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight 2017, 2: e95913. PMID: 29046482, PMCID: PMC5846903, DOI: 10.1172/jci.insight.95913.Peer-Reviewed Original ResearchConceptsGlucose levelsPlasma free fatty acid levelsSimilar plasma glucose levelsFree fatty acid levelsCerebral glucose metabolismPlasma glucose levelsBrain glucose levelsFatty acid levelsAltered feeding behaviorGlucose incrementHyperglycemic clampBrain glucoseCerebral functionLean participantsOccipital lobeRodent modelsGlucose metabolismObesityT2DMGlucose responseHyperglycemiaNeurocognitive consequencesSimilar findingsAcid levelsIntracerebral glucose
1994
Effects of puberty and diabetes on metabolism of insulin-sensitive fuels
Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, Tamborlane WV. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. American Journal Of Physiology 1994, 266: e885-e891. PMID: 8023918, DOI: 10.1152/ajpendo.1994.266.6.e885.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusIDDM adolescentsEffect of pubertyGlucose metabolismNondiabetic groupIDDM subjectsInsulin infusionHealthy controlsLeucine fluxHealthy young adult controlsLow-dose insulin infusionPlasma free fatty acid levelsFree fatty acid levelsYoung adult controlsFatty acid levelsAction of insulinLeucine oxidation rateAmino acid/protein metabolismEuglycemic hyperinsulinemiaDiabetes mellitusInsulin resistanceInsulin valuesBasal glucosePlasma insulinNormal puberty
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