2020
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling
Latorraca N, Masureel M, Hollingsworth S, Heydenreich F, Suomivuori C, Brinton C, Townshend R, Bouvier M, Kobilka B, Dror R. How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling. Cell 2020, 183: 1813-1825.e18. PMID: 33296703, PMCID: PMC7901245, DOI: 10.1016/j.cell.2020.11.014.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsPhosphorylation patternActivation-associated conformational changesSite-directed spectroscopyPhosphorylated G protein-coupled receptorsG protein-coupled receptor phosphorylationBinding of arrestinArrestin sitesSignaling proteinsCell signalingStructural basisArrestin conformationArrestin bindingMolecular mechanismsPhosphorylationArrestinConformational changesGPCR-targeted drugsBindingBarcodingConformationProteinAtomic-level simulationsSignalPatterns
2007
Allelic variant in CTLA4 alters T cell phosphorylation patterns
Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA. Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 18607-18612. PMID: 18000051, PMCID: PMC2141824, DOI: 10.1073/pnas.0706409104.Peer-Reviewed Original ResearchConceptsT cell antigen receptorAllelic variationMemory T cellsAutoimmune diseasesCell antigen receptorT cell signalingT cellsFunctional effectsDisease susceptibility allelesCell signalingPhosphorylation patternPhosphorylation levelsSusceptibility variantsTCR stimulationAllelic variantsHuman immune cellsAntigen receptorGenesImmune cellsHealthy individualsCTLA4 geneCellsSpecific mAbsCTLA4Disease
2005
Chlamydial Infection Induces Pathobiotype-Specific Protein Tyrosine Phosphorylation in Epithelial Cells
Virok D, Nelson D, Whitmire W, Crane D, Goheen M, Caldwell H. Chlamydial Infection Induces Pathobiotype-Specific Protein Tyrosine Phosphorylation in Epithelial Cells. Infection And Immunity 2005, 73: 1939-1946. PMID: 15784533, PMCID: PMC1087445, DOI: 10.1128/iai.73.4.1939-1946.2005.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphorylationProtein tyrosine phosphorylation patternPattern of protein tyrosine phosphorylationTyrosine phosphorylation patternsTyrosine phosphorylationPhosphorylation patternLevel of genomic syntenyPathogen host rangeTissue tropismMammalian host cellsObligate intracellular pathogenHuman epithelial cellsGenomic syntenyEpithelial cellsPhosphorylated protein(sLymphogranuloma venereum biovarsBacterial moleculesHost rangeDisease tropismHost cellsC. caviaeChlamydial originIntracellular pathogensPhosphorylationGenus Chlamydia
2001
Temperature Dependence of the Epidermal Growth Factor Receptor Signaling Network Can Be Accounted for by a Kinetic Model †
Moehren G, Markevich N, Demin O, Kiyatkin A, Goryanin I, Hoek JB, Kholodenko BN. Temperature Dependence of the Epidermal Growth Factor Receptor Signaling Network Can Be Accounted for by a Kinetic Model †. Biochemistry 2001, 41: 306-320. PMID: 11772030, DOI: 10.1021/bi011506c.Peer-Reviewed Original ResearchConceptsEpidermal growth factorEGF receptorEGFR kinaseDomain-mediated interactionsEGF receptor dimerizationProtein-protein interactionsRapid tyrosine phosphorylationMultiple signaling proteinsEGFR kinase activityReceptor phosphataseSignaling networksSignaling proteinsProtein interactionsPhosphorylation patternTyrosine phosphorylationReceptor dimerizationKinase activityTarget proteinsMembrane lipidsMolecular termsDephosphorylation reactionsEGFR pathwayPhosphataseKinasePhosphorylation
1997
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.
Sun X, Pons S, Wang L, Zhang Y, Yenush L, Burks D, Myers M, Glasheen E, Copeland N, Jenkins N, Pierce J, White M. The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Endocrinology 1997, 11: 251-62. PMID: 9013772, DOI: 10.1210/mend.11.2.9885.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAmino Acid SequenceAnimalsBase SequenceCell DifferentiationCells, CulturedChromosome MappingChromosomesCytokinesInsulinInsulin Receptor Substrate ProteinsInterleukin-4Intracellular Signaling Peptides and ProteinsMiceMolecular Sequence DataPhosphoproteinsPhosphorylationSequence Homology, Amino AcidSignal TransductionTissue DistributionTyrosineConceptsMurine chromosome 8IRS-2IRS-1IRS-2 geneIRS proteinsExpression patternsSrc homology 2 domainChromosome 8Recombinant SH2 domainsSpecific expression patternsMurine chromosome 1Amino acid sequenceDifferential tyrosine phosphorylationMurine hematopoietic cellsDistinct phosphorylation patternsSH2 domainSignal transductionSingle exonPhosphorylation patternTyrosine phosphorylationIL-4 stimulationAcid sequenceChromosome 1Signaling adapterCytokine signaling
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