How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling
Latorraca N, Masureel M, Hollingsworth S, Heydenreich F, Suomivuori C, Brinton C, Townshend R, Bouvier M, Kobilka B, Dror R. How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling. Cell 2020, 183: 1813-1825.e18. PMID: 33296703, PMCID: PMC7901245, DOI: 10.1016/j.cell.2020.11.014.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsPhosphorylation patternActivation-associated conformational changesSite-directed spectroscopyPhosphorylated G protein-coupled receptorsG protein-coupled receptor phosphorylationBinding of arrestinArrestin sitesSignaling proteinsCell signalingStructural basisArrestin conformationArrestin bindingMolecular mechanismsPhosphorylationArrestinConformational changesGPCR-targeted drugsBindingBarcodingConformationProteinAtomic-level simulationsSignalPatterns
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