The pathway of unconventional protein secretion involves CUPS and a modified trans-Golgi network
Curwin A, Kurokawa K, Bigliani G, Brouwers N, Nakano A, Malhotra V. The pathway of unconventional protein secretion involves CUPS and a modified trans-Golgi network. Journal Of Cell Biology 2025, 224: e202312120. PMID: 40015244, PMCID: PMC11867701, DOI: 10.1083/jcb.202312120.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkUnconventional protein secretionUnconventional secretionSuper-resolution confocal live imaging microscopyProtein secretionPhosphatidylinositol 3-phosphatePhosphatidylinositol 4-phosphateExtracts of membranesGolgi membranesConventional secretionGolgi cisternaeMembrane fusionSecreted proteinsCup formationPI4PRCY1Drs2GolgiProteinPhosphatidylinositolSecretionMembraneCOPIIImaging microscopyBiogenesis
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