1993
Comparative Effects of Monomethylsuccinate and Glucose on Insulin Secretion from Perifused Rat Islets
Zawalich W, Zawalich K, Cline G, Shulman G, Rasmussen H. Comparative Effects of Monomethylsuccinate and Glucose on Insulin Secretion from Perifused Rat Islets. Diabetes 1993, 42: 843-850. PMID: 8388341, DOI: 10.2337/diab.42.6.843.Peer-Reviewed Original ResearchConceptsPhosphoinositide hydrolysisInsulin secretionCalcium channel antagonist nitrendipineChannel antagonist nitrendipinePerifused rat isletsCalcium channel antagonistsSecond phase releaseGut hormone cholecystokininFirst-phase releaseInsulinotropic effectAntagonist nitrendipineSulfonylurea tolbutamideChannel antagonistsInsulin releaseHormone cholecystokininSubsequent stimulationGlucose-induced responseRat isletsSustained increaseStimulatory effectBiphasic patternMM glucoseMMSuccSecretionMonomethylsuccinateGlucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation
Ortmeyer J, Mohsenin V. Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation. American Journal Of Physiology 1993, 264: c402-c410. PMID: 8383432, DOI: 10.1152/ajpcell.1993.264.2.c402.Peer-Reviewed Original ResearchConceptsNormal neutrophilsActivation of PLDNADPH oxidaseTreatment of neutrophilsReceptor-mediated stimulationN-formyl-MetPLD activationDiabetic subjectsFormation of inositolReceptor stimulationPhosphoinositide hydrolysisGlucose suppressesIntracellular Ca2NeutrophilsPhospholipase D activationMarked inhibitionLeu-PhePhospholipase D activityGeneration of O2D activationNonmetabolizable sugarPhosphatidic acidSuperoxide anionActivationGlucose
1989
Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets.
Pardi R, Bender J, Dettori C, Giannazza E, Engleman E. Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets. The Journal Of Immunology 1989, 143: 3157-66. PMID: 2553807, DOI: 10.4049/jimmunol.143.10.3157.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, DifferentiationCell AdhesionCell MembraneCross-Linking ReagentsEndothelium, VascularHumansHydrolysisInterphaseLymphocyte Function-Associated Antigen-1LymphocytesMembrane GlycoproteinsN-Acetylneuraminic AcidPhosphatidylinositolsReceptors, Leukocyte-AdhesionSialic AcidsSignal TransductionStructure-Activity RelationshipConceptsLymphocyte subsetsLFA-1Lymphocyte function-associated antigenDifferent lymphocyte subsetsHuman lymphocyte subsetsFunction-associated antigenAnti-beta subunit antibodiesCell surface densityPhosphoinositide hydrolysisSialic acid contentSubunit antibodiesVariable expressionIntegrin supergene familyLFA-1 alpha subunitNatural ligandCell bindingNeuraminidase digestionActivation eventsRelative increaseAlpha subunitSupergene familySubsetBeta subunitReceptor-mediated phosphoinositide hydrolysis in human ocular ciliary epithelial cells.
Wax M, Coca-Prados M. Receptor-mediated phosphoinositide hydrolysis in human ocular ciliary epithelial cells. Investigative Ophthalmology & Visual Science 1989, 30: 1675-9. PMID: 2545648.Peer-Reviewed Original ResearchConceptsPI hydrolysisReceptor-mediated phosphoinositide hydrolysisEpithelial cellsSelective muscarinic antagonistsInositol phosphatesAccumulation of inositolHydrolysis of phosphoinositidesOcular ciliary epitheliumAFDX-116M3 subtypeMuscarinic antagonistMuscarinic receptorsPutative neurotransmittersEC50 valuesPharmacologic characteristicsCiliary epithelial cellsPeripheral tissuesSpecific antagonistPI breakdownPhosphoinositide hydrolysisArginine vasopressinNonpigmented layerOcular ciliary epithelial cellsCiliary epitheliumMicroCi/
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