2020
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production. Nature Neuroscience 2020, 23: 1555-1566. PMID: 33199896, DOI: 10.1038/s41593-020-00735-y.Peer-Reviewed Original ResearchConceptsReactive astrocytesAlzheimer's diseaseAPP/PS1 micePathogenesis of ADReactivity of astrocytesBrains of patientsAppropriate experimental modelsGlial activationPS1 miceAstrocytic reactivityBrain atrophyPathological featuresNeuronal deathMonoamine oxidase BPathological hallmarkAD modelPrecise molecular mechanismsAnimal modelsAstrocytesCognitive impairmentPathological contributionExperimental modelDiseaseOxidase BEventual death
1985
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.
Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 2173-2177. PMID: 3872460, PMCID: PMC397515, DOI: 10.1073/pnas.82.7.2173.Peer-Reviewed Original ResearchConceptsDopamine neuronsCortical synaptosomesParkinsonism-inducing neurotoxinNigrostriatal dopamine neuronsCerebral cortical synaptosomesMetabolite N-methylNorepinephrine uptake systemMetabolite of MPTPPotency of drugsIdiopathic parkinsonismStriatal synaptosomesClinical abnormalitiesMonoamine oxidase BNucleus accumbensRat brainRat striatumDopamine uptakeMPTPN-methylSelective destructionSynaptosomesNeuronsOxidase BTetrahydropyridineSelective toxicity
1979
DOPAMINE OXIDATION AND ITS INHIBITION BY (−)-DEPRENYL IN HUMAN BRAIN AND TISSUES
Glover V, Elsworth J, Sandler M. DOPAMINE OXIDATION AND ITS INHIBITION BY (−)-DEPRENYL IN HUMAN BRAIN AND TISSUES. 1979, 201-203. DOI: 10.1016/b978-1-4832-8363-0.50063-x.Peer-Reviewed Original Research
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