Inhibition of Restenosis Development after Mechanical Injury: A New Field of Application for Malononitrilamides?
Schrepfer S, Deuse T, Sultan K, Haddad M, Böger R, Münzel T, Schäfer H, Pelletier M, Robbins R, Reichenspurner H. Inhibition of Restenosis Development after Mechanical Injury: A New Field of Application for Malononitrilamides? Cardiology 2006, 108: 128-137. PMID: 17028423, DOI: 10.1159/000096037.Peer-Reviewed Original ResearchMeSH KeywordsAlkynesAnimalsAorta, AbdominalCarrier ProteinsCell MovementCell ProliferationEndothelium, VascularGraft Occlusion, VascularHyperplasiaImmunosuppressive AgentsIsoxazolesMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNitrilesRatsRats, Inbred LewRNA, MessengerSirolimusSmad7 ProteinTacrolimusTransforming Growth Factor beta1Tunica IntimaVasodilationVasodilator AgentsConceptsSmooth muscle cellsMalononitrilamide FK778Restenosis developmentVascular fibrosisSmooth muscle cell proliferation/migrationAcetylcholine dose responseVascular smooth muscle cellsAntimigratory effectsOrgan chamber studiesIn vivoProfibrotic gene expressionIntimal hyperplasiaPercutaneous transluminal coronary angioplastyRate of restenosisIn vitro studiesFK778 treatmentTransluminal coronary angioplastyLuminal obliterationFK778Endothelial dysfunctionAbdominal aortaMuscle cellsHistological evaluationNeointima formationSynthesis blockade
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