2018
Pharmacokinetic Characteristics of Tofacitinib in Adult Patients With Moderate to Severe Chronic Plaque Psoriasis
Ma G, Xie R, Strober B, Langley R, Ito K, Krishnaswami S, Wolk R, Valdez H, Rottinghaus S, Tallman A, Gupta P. Pharmacokinetic Characteristics of Tofacitinib in Adult Patients With Moderate to Severe Chronic Plaque Psoriasis. Clinical Pharmacology In Drug Development 2018, 7: 587-596. PMID: 29856518, DOI: 10.1002/cpdd.471.Peer-Reviewed Original ResearchConceptsSeparate phase 1 studySevere chronic plaque psoriasisOral Janus kinase inhibitorPharmacokinetics of tofacitinibChronic plaque psoriasisApparent oral clearancePhase 1 studyVd/FCL/FJanus kinase inhibitorFull covariate modelZero-order absorptionOne-compartment modelBaseline PASITofacitinib pharmacokineticsPlaque psoriasisRenal impairmentAdult patientsOral clearancePatient factorsBaseline variablesPharmacokinetic characteristicsBody weightApparent volumeInterindividual variability
2000
9:30—9:45 First Pass FDG Measured Blood Flow in Tumors: A Comparison with O-15 Labeled Water Measured Blood Flow
Mullani N, Herbst R, Abbruzzese J, Barron B, Lamki L, Charnsangavej C, Kim E, Tran H, Jiwani A, Gould K. 9:30—9:45 First Pass FDG Measured Blood Flow in Tumors: A Comparison with O-15 Labeled Water Measured Blood Flow. Molecular Imaging And Biology 2000, 3: 153. PMID: 11150756, DOI: 10.1016/s1095-0397(00)00065-0.Peer-Reviewed Original ResearchBlood flowRegional blood flowNovel antiangiogenic agentsBlood flow valuesOne-compartment modelMeasured blood flowAbsence of perfusionBlood flow tracerPerfusion scanEstimate of perfusionBolus injectionAntiangiogenic agentsPET scansTumor perfusionMCi doseLinear regression analysisFDGTumor sitePhase IPerfusion tracerPerfusionTumorsTwo minutesScansRegression analysis
1987
Antipyrine Clearance: Evaluation of Simplified Methods in Chronic Liver Diseases
Strazzabosco M, Muraca M, Venuti M, Varotto A, Nassuato G, Iemmolo R, Orlando R, Lirussi F, Manzati C, Crimella T, Iaccheri E, Bernardi R, Okolicsányi L. Antipyrine Clearance: Evaluation of Simplified Methods in Chronic Liver Diseases. 1987, 197-204. DOI: 10.1007/978-3-642-72631-6_26.Peer-Reviewed Original ResearchLiver diseaseAntipyrine clearanceChronic liver diseaseHepatic blood flowHepatic drug metabolismHepatic microsomal enzymesLarge interindividual variationOne-compartment modelSurgical riskLiver functionClinical hepatologyTotal body waterLiver patientsBlood flowDistribution volumeDrug metabolismPrognostic purposesInterindividual variationMicrosomal enzymesBody waterDiseaseClearancePatientsUnique kinetic propertiesHepatology
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