2024
Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis
Sun Y, King B, Hamlin A, Saniepay M, Gorshkov K, Barker G, Ziegler M, Mukundan S, Cvijic M, Schwarzbauer J. Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis. Cells And Development 2024, 179: 203941. PMID: 39038657, PMCID: PMC11344656, DOI: 10.1016/j.cdev.2024.203941.Peer-Reviewed Original ResearchConceptsFn-binding proteinsExtracellular matrixInsulin-like growth factor binding protein-3Extracellular matrix protein fibronectinLevels of ECM proteinsExtracellular matrix proteinsIn vivo diseaseMatrisome genesEDB exonsProtein fibronectinECM proteinsRNA sequencingGene expressionTGF-bDown-regulationProteinHuman lung fibroblastsUp-regulatedLevels of FNProtein signaturesFibronectinFN expressionGrowth factor binding protein-3ExonAssociated with idiopathic pulmonary fibrosis
2003
Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis
Selman M, Lin H, Montaño M, Jenkins A, Estrada A, Lin Z, Wang G, DiAngelo S, Guo X, Umstead T, Lang C, Pardo A, Phelps D, Floros J. Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis. Human Genetics 2003, 113: 542-550. PMID: 13680361, DOI: 10.1007/s00439-003-1015-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotidePulmonary FibrosisPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CPulmonary Surfactant-Associated Protein DSpectrophotometryConceptsSingle nucleotide polymorphismsAmino acidsIdiopathic pulmonary fibrosisSP-A1Innate host defenseGenetic polymorphic variantsMicrosatellite markersProtein variantsTruncated proteinSP-A2SP-BNucleotide polymorphismsGenetic variantsSurfactant proteinsSurfactant protein AHost defenseSP-CProtein behaviorProtein APulmonary fibrosisSP-D.ProteinSP-A proteinRisk factorsAssociated with idiopathic pulmonary fibrosis
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