2024
Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis
Sun Y, King B, Hamlin A, Saniepay M, Gorshkov K, Barker G, Ziegler M, Mukundan S, Cvijic M, Schwarzbauer J. Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis. Cells And Development 2024, 179: 203941. PMID: 39038657, PMCID: PMC11344656, DOI: 10.1016/j.cdev.2024.203941.Peer-Reviewed Original ResearchConceptsFn-binding proteinsExtracellular matrixInsulin-like growth factor binding protein-3Extracellular matrix protein fibronectinLevels of ECM proteinsExtracellular matrix proteinsIn vivo diseaseMatrisome genesEDB exonsProtein fibronectinECM proteinsRNA sequencingGene expressionTGF-bDown-regulationProteinHuman lung fibroblastsUp-regulatedLevels of FNProtein signaturesFibronectinFN expressionGrowth factor binding protein-3ExonAssociated with idiopathic pulmonary fibrosis
1998
Immunofluorescence Characterization of Key Extracellular Matrix Proteins in Murine Bone Marrow In Situ
Nilsson S, Debatis M, Dooner M, Madri J, Quesenberry P, Becker P. Immunofluorescence Characterization of Key Extracellular Matrix Proteins in Murine Bone Marrow In Situ. Journal Of Histochemistry & Cytochemistry 1998, 46: 371-377. PMID: 9487119, DOI: 10.1177/002215549804600311.Peer-Reviewed Original ResearchConceptsExtracellular matrix proteinsMatrix proteinsKey extracellular matrix proteinsParticular extracellular matrix proteinsExtracellular matrix protein fibronectinStem cellsCentral marrow regionsMatrix protein fibronectinStem cell proliferationCollagen type IMurine bone marrowHemopoietic stem cellsProtein fibronectinBone marrow vesselsExtracellular matrixBone marrowMechanistic roleCell proliferationProteinMarrow microenvironmentImportant mechanistic roleMolecular interactionsImmunofluorescence labelingCollagen type IVType I
1996
Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport
Lewis J, Baskaran R, Taagepera S, Schwartz M, Wang J. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 15174-15179. PMID: 8986783, PMCID: PMC26376, DOI: 10.1073/pnas.93.26.15174.Peer-Reviewed Original ResearchConceptsNuclear c-AblC-AblKinase activityC-Abl tyrosine kinase activityTyrosine kinaseCell adhesionCell cycle signalsCytoplasmic-nuclear transportExtracellular matrix protein fibronectinNonreceptor tyrosine kinaseCytoplasmic c-AblC-Abl activationC-Abl activityMatrix protein fibronectinTyrosine kinase activityC-abl protooncogeneMin of adhesionIntegrin regulationSubcellular localizationIntegrin signalsFocal contactsCytoplasmic poolTransient recruitmentSubcellular distributionProtein fibronectin
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