2023
Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma
Petrylak D, Eigl B, George S, Heath E, Hotte S, Chism D, Nabell L, Picus J, Cheng S, Appleman L, Sonpavde G, Morgans A, Pourhosseini P, Wu R, Standley L, Croitoru R, Yu E. Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma. Clinical Cancer Research 2023, 30: of1-of11. PMID: 37861407, PMCID: PMC10767306, DOI: 10.1158/1078-0432.ccr-22-3627.Peer-Reviewed Original ResearchConceptsMetastatic urothelial carcinomaObjective response rateDose-limiting toxicityAntibody-drug conjugatesUrothelial carcinomaCommon treatment-emergent adverse eventsInvestigational antibody-drug conjugateTreatment-emergent adverse eventsI dose-escalation studyDose-expansion cohortsCheckpoint inhibitor therapyPhase II doseDose-escalation studyDose-proportional mannerMultiple-dose administrationBest overall responseMonomethyl auristatin ECytotoxic drug monomethyl auristatin EPrior chemotherapyAdverse eventsDose escalationInhibitor therapyPeripheral neuropathyOcular toxicityExpansion trial
2022
Strategies to mitigate the toxicity of cancer therapeutics
Kahn AM, Blenman KRM, Sonis ST, Lustberg MB. Strategies to mitigate the toxicity of cancer therapeutics. Advances In Cancer Research 2022, 155: 215-244. PMID: 35779875, DOI: 10.1016/bs.acr.2022.02.006.Peer-Reviewed Original ResearchConceptsAromatase inhibitor-induced musculoskeletal symptomsChemotherapy-induced peripheral neuropathyCancer-related cognitive impairmentCancer treatment symptomsOral mucosal toxicityImmune checkpoint inhibitionTyrosine kinase inhibitorsCancer therapeuticsGastrointestinal toxicityMucosal toxicityAdverse eventsHormone therapySystemic therapyTreatment toxicityPeripheral neuropathyCheckpoint inhibitionSymptom managementMusculoskeletal symptomsRenal toxicityTreatment symptomsOcular toxicityTreatment modalitiesTraditional chemotherapyCognitive impairmentMonoclonal antibodies
2017
Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft
Kim JW, Jacobsen B, Zolfaghari E, Ferrario A, Chevez-Barrios P, Berry JL, Lee DK, Rico G, Madi I, Rao N, Stachelek K, Wang LC, Gomer C. Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft. Graefe's Archive For Clinical And Experimental Ophthalmology 2017, 255: 2363-2373. PMID: 28971251, DOI: 10.1007/s00417-017-3805-8.Peer-Reviewed Original ResearchConceptsRetinoblastoma xenograftsRabbit retinaPhotodynamic therapyLaser delivery systemTreatment of retinoblastomaPre-clinical studiesPhase 1Intraocular retinoblastomaIntravenous verteporfinRetinal scarsSubretinal tumorsDelivery systemRetinal damageRight eyeHistopathologic examinationOcular toxicityTumor necrosisOcular damageControl rabbitsTreatment durationRabbit modelVerteporfinWavelength diode laserThermal burnsPDT treatment
2009
NCCN Task Force Report: Management of dermatologic and other toxicities associated with EGFR inhibition in patients with cancer.
Burtness B, Anadkat M, Basti S, Hughes M, Lacouture ME, McClure JS, Myskowski PL, Paul J, Perlis CS, Saltz L, Spencer S. NCCN Task Force Report: Management of dermatologic and other toxicities associated with EGFR inhibition in patients with cancer. Journal Of The National Comprehensive Cancer Network 2009, 7 Suppl 1: s5-21; quiz s22-4. PMID: 19470276, DOI: 10.6004/jnccn.2009.0074.Peer-Reviewed Original ResearchConceptsTask force membersEGFR inhibitorsEpidermal growth factor receptor inhibitorsGrowth factor receptor inhibitorsNCCN Member InstitutionsOphthalmologic toxicityOncology providersOcular toxicityClinical trialsDifferent etiologiesReceptor inhibitorsEGFR inhibitionPatientsTask Force ReportTherapyToxicityInhibitorsSimilar toxicityTask ForceForce ReportReportExpert opinionOncologistsEtiologyOphthalmologistsAn exploratory study of the safety, tolerability and bioactivity of a single intravitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema
V D, Nguyen QD, Shah SM, Browning DJ, Haller JA, Chu K, Yang K, Cedarbaum JM, Vitti RL, Ingerman A, Campochiaro PA. An exploratory study of the safety, tolerability and bioactivity of a single intravitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema. British Journal Of Ophthalmology 2009, 93: 144. PMID: 19174400, DOI: 10.1136/bjo.2008.138271.Peer-Reviewed Original ResearchConceptsVEGF Trap-EyeDiabetic macular edemaSingle intravitreal injectionVascular endothelial growth factor (VEGF) Trap-EyeExcess foveal thicknessFoveal thicknessIntravitreal injectionOptical coherence tomographyMacular edemaUnrelated serious adverse eventsMedian baseline BCVASerious adverse eventsBaseline BCVAETDRS lettersAdverse eventsRetinal thicknessVisual acuityOcular toxicityOutcome measuresBCVAMedian improvementPatientsCoherence tomographyAdditional studiesObservation period
2007
Ethambutol Neuroretinopathy
Vistamehr S, Walsh TJ, Adelman RA. Ethambutol Neuroretinopathy. Seminars In Ophthalmology 2007, 22: 141-146. PMID: 17763233, DOI: 10.1080/08820530701457134.Peer-Reviewed Original ResearchConceptsElectrophysiological findingsRetinal pigment epithelial changesAbnormal Arden ratioElectro-oculogram findingsFlame-shaped hemorrhagesPigment epithelial changesFull-field ERGAbnormal wave patternRetinal findingsElectroretinogram findingsMacular edemaClinical featuresEpithelial changesCase reportOcular toxicityPattern ERGArden ratioNeuroretinopathyVisual fieldToxic effectsFindingsEdemaHemorrhagePatientsEthambutol
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply