2024
Expanding RNA editing toolkit using an IDR-based strategy
Di M, Lv J, Jing Z, Yang Y, Yan K, Wu J, Ge J, Rauch S, Dickinson B, Chi T. Expanding RNA editing toolkit using an IDR-based strategy. Molecular Therapy - Nucleic Acids 2024, 35: 102190. PMID: 38721279, PMCID: PMC11077028, DOI: 10.1016/j.omtn.2024.102190.Peer-Reviewed Original Research
2021
Genome-wide detection and analysis of CRISPR-Cas off-targets
Rodríguez T, Dadafarin S, Pratt H, Liu P, Amrani N, Zhu L. Genome-wide detection and analysis of CRISPR-Cas off-targets. Progress In Nucleic Acid Research And Molecular Biology 2021, 181: 31-43. PMID: 34127199, DOI: 10.1016/bs.pmbts.2021.01.012.Peer-Reviewed Original ResearchConceptsProtospacer-adjacent motifOff-target identificationGUIDE-seqGenome-wide detectionHigh-throughput sequencingShort Palindromic Repeats (CRISPR) technologyOff-target sitesSequencing platformsThroughput sequencingTreat human diseasesOpen-source pipelineDocker imageHuman diseasesGene editingOff-targetsBiological studiesIncreased multiplexingProfiling approachSequenceIn vivoBioconductorSgRNAMotifRNAIdentification
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply