2022
Delta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior
Ganesh S, Cortes-Briones J, Martin A, Skosnik PD, D'Souza DC, Ranganathan M. Delta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior. Cannabis And Cannabinoid Research 2022, 8: 846-856. PMID: 35319274, PMCID: PMC10589482, DOI: 10.1089/can.2021.0166.Peer-Reviewed Original ResearchConceptsPsychotomimetic effectsHuman laboratory studiesDifferent dose ratiosDose-related interactionDelta-9-TetrahydrocannabinolLower CBDNeural noiseRatio-dependent mannerCannabis liberalizationHealthy volunteersElectrophysiological biomarkersMedical indicationsPsychotomimetic statesSpecific brainDose ratioPrior exposureObjective effectsHuman brainMaximal attenuationBrainTHCAntagonistic effectCannabis plantNeuroscience investigationsBehavioral responses
1996
Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response
Cain W, Leaderer B, Ginsberg G, Andrews L, Cometto-muñiz J, Gent J, Buck M, Berglund L, Mohsenin V, Monahan E, Kjaergaard S. Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response. Inhalation Toxicology 1996, 8: 21-48. DOI: 10.3109/08958379609005425.Peer-Reviewed Original ResearchDouble-blind studyEnd of exposureNasal inflammationBlood levelsAcute exposureComputerized performance testsHealthy adultsPharmacokinetic responseEye irritationSymptomsPharmacokinetic studyMethyl tertiary butyl etherDifferential effectsObjective effectsObjective correlatesExposureSubjectsPMNTertiary butyl etherOne-halfSubjects' ratingsInflammationLevelsBloodBaseline
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