Site-specific cation release drives actin filament severing by vertebrate cofilin
Kang H, Bradley MJ, Cao W, Zhou K, Grintsevich EE, Michelot A, Sindelar CV, Hochstrasser M, De La Cruz EM. Site-specific cation release drives actin filament severing by vertebrate cofilin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 17821-17826. PMID: 25468977, PMCID: PMC4273407, DOI: 10.1073/pnas.1413397111.Peer-Reviewed Original ResearchConceptsFilament severingActin filamentsActin filament severingKey regulatory functionsConcentration of endsActin filament fragmentationEukaryotic cellsCation-binding sitesProtein cofilinDeletion mutantsS. cerevisiaeSubunit exchangeFilament turnoverActin polymerizationEssential functionsSite-specific interactionsCofilinMolecular mechanismsAssembly dynamicsRegulatory functionsActin moleculesFilament fragmentationFilament structureSustained motilitySeveringSpire and Formin 2 Synergize and Antagonize in Regulating Actin Assembly in Meiosis by a Ping-Pong Mechanism
Montaville P, Jégou A, Pernier J, Compper C, Guichard B, Mogessie B, Schuh M, Romet-Lemonne G, Carlier M. Spire and Formin 2 Synergize and Antagonize in Regulating Actin Assembly in Meiosis by a Ping-Pong Mechanism. PLOS Biology 2014, 12: e1001795. PMID: 24586110, PMCID: PMC3934834, DOI: 10.1371/journal.pbio.1001795.Peer-Reviewed Original ResearchConceptsBarbed endsCaps filament barbed endsFilament barbed endsRegulate actin assemblyActin assembly dynamicsActin-binding proteinsRab11a-positive vesiclesPresence of actinPing-pong mechanismMechanisms of regulationActin assemblyActin meshworkFormin 2Fmn2ForminBinding proteinAssembly dynamicsArrested growthMolecular mechanismsActinMeiotic spindleProfilinMammalian oocytesProcess assemblyMouse oocytes
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