2025
Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study
Lee H, Tzuang M, Chow T, Kang Y, Tee B, Li C, Lam E, Gu Y, Lee S, Ho P, Peavy G, Seo E, Kim K, Tran B, Chae W, Nguyen D, Vo N, Dang D, Spat‐Lemus J, Choi Y, Feldman H, Jun G, Wang L, Yu W, Park V, Study T. Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study. Alzheimer's & Dementia 2025, 21: e70311. PMID: 40528300, PMCID: PMC12173839, DOI: 10.1002/alz.70311.Peer-Reviewed Original ResearchConceptsCultural adaptationWorld Health OrganizationPromote health literacyCanadian older adultsAsian cohortCulturally appropriate translationCognitive assessment toolsLanguage backgroundAsian languagesAppropriate translationAssessment of cognitive functionHealth literacyStudy materialQuality healthcareCanadian adultsAlzheimer's diseaseTranslation processTranslation guidelinesOlder adultsSociocultural backgroundTranslation methodologyCanadian populationLanguage versionsAdaptation of toolsAssessment toolGenomics yields biological and phenotypic insights into bipolar disorder
Lee B, Kim J, Lee Y, Kang J, Cheon M, Kim D, Aslan M, Harvey P, Huang G. Genomics yields biological and phenotypic insights into bipolar disorder. Nature 2025, 639: 968-975. PMID: 39843750, PMCID: PMC12163093, DOI: 10.1038/s41586-024-08468-9.Peer-Reviewed Original ResearchFine-mappingGenetic architectureGenome-wide significant lociMulti-ancestry meta-analysisGenetic architecture of bipolar disorderRare variant signalsSignificant lociGenetic determinantsBipolar disorderVariant signalsLatino ancestryCell typesEast Asian cohortsPhenotypic insightsPathophysiology of bipolar disorderGenesMedium spiny neuronsBipolar disorder subtypesPatient ascertainmentAetiology of bipolar disorderGABAergic interneuronsSpiny neuronsAsian cohortGenomeGlobal burden
2024
Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians
Ho P, Yu W, Tee B, Lee W, Li C, Gu Y, Yokoyama J, Reyes‐Dumeyer D, Choi Y, Yang H, Vardarajan B, Tzuang M, Lieu K, Lu A, Faber K, Potter Z, Revta C, Kirsch M, McCallum J, Mei D, Booth B, Cantwell L, Chen F, Chou S, Clark D, Deng M, Hong T, Hwang L, Jiang L, Joo Y, Kang Y, Kim E, Kim H, Kim K, Kuzma A, Lam E, Lanata S, Lee K, Li D, Li M, Li X, Liu C, Liu C, Liu L, Lupo J, Nguyen K, Pfleuger S, Qian J, Qian W, Ramirez V, Russ K, Seo E, Song Y, Tartaglia M, Tian L, Torres M, Vo N, Wong E, Xie Y, Yau E, Yi I, Yu V, Zeng X, St George‐Hyslop P, Au R, Schellenberg G, Dage J, Varma R, Hsiung G, Rosen H, Henderson V, Foroud T, Kukull W, Peavy G, Lee H, Feldman H, Mayeux R, Chui H, Jun G, Park V, Chow T, Wang L. Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians. Alzheimer's & Dementia 2024, 20: 2058-2071. PMID: 38215053, PMCID: PMC10984480, DOI: 10.1002/alz.13611.Peer-Reviewed Original ResearchConceptsAD risk factorsCulturally appropriate recruitment strategiesRisk factorsNon-genetic risk factorsAsian cohortAsian AmericansClinical researchMulti-ethnic populationAlzheimer's diseaseClinical trial readinessCentral coordination siteRecruitment strategiesProgram's inceptionExpressed interestTrial readinessData collection protocolsPromote awarenessRecruitment sitesCohort diversityStudy protocolPilot studyHealth crisisCentralized data management systemComprehensive study protocolRecruitment programs
2023
Lung Cancer Risk Prediction Models for Asian Ever-Smokers
Yang J, Wen W, Zahed H, Zheng W, Lan Q, Abe S, Rahman M, Islam M, Saito E, Gupta P, Tamakoshi A, Koh W, Gao Y, Sakata R, Tsuji I, Malekzadeh R, Sugawara Y, Kim J, Ito H, Nagata C, You S, Park S, Yuan J, Shin M, Kweon S, Yi S, Pednekar M, Kimura T, Cai H, Lu Y, Etemadi A, Kanemura S, Wada K, Chen C, Shin A, Wang R, Ahn Y, Shin M, Ohrr H, Sheikh M, Blechter B, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Inoue M, Kang D, Robbins H, Shu X. Lung Cancer Risk Prediction Models for Asian Ever-Smokers. Journal Of Thoracic Oncology 2023, 19: 451-464. PMID: 37944700, PMCID: PMC11126207, DOI: 10.1016/j.jtho.2023.11.002.Peer-Reviewed Original ResearchLow-intensity smokersLong-term quittersLung cancer riskRisk prediction modelProspective cohortCancer riskPopulation-based prospective cohortLung cancer risk prediction modelsLung cancer prediction modelsCancer risk prediction modelsRisk-based screeningRisk assessment toolEver smokersPooled analysisCancer prediction modelAsian cohortSmokersHighest AUCWestern populationsAsian populationsCohortGood calibrationQuittersAssessment toolRisk
2021
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs
Cordell H, Fryett J, Ueno K, Darlay R, Aiba Y, Hitomi Y, Kawashima M, Nishida N, Khor S, Gervais O, Kawai Y, Nagasaki M, Tokunaga K, Tang R, Shi Y, Li Z, Juran B, Atkinson E, Gerussi A, Carbone M, Asselta R, Cheung A, de Andrade M, Baras A, Horowitz J, Ferreira M, Sun D, Jones D, Flack S, Spicer A, Mulcahy V, Byan J, Han Y, Sandford R, Lazaridis K, Amos C, Hirschfield G, Seldin M, Invernizzi P, Siminovitch K, Ma X, Nakamura M, Mells G, Consortia P, Consortium C, Siminovitch K, Mason A, Vincent C, Xie G, Zhang J, Consortium C, Tang R, Ma X, Li Z, Shi Y, Group I, Affronti A, Almasio P, Alvaro D, Andreone P, Andriulli A, Azzaroli F, Battezzati P, Benedetti A, Bragazzi M, Brunetto M, Bruno S, Calvaruso V, Cardinale V, Casella G, Cazzagon N, Ciaccio A, Coco B, Colli A, Colloredo G, Colombo M, Colombo S, Cristoferi L, Cursaro C, Crocè L, Crosignani A, D’Amato D, Donato F, Elia G, Fabris L, Fagiuoli S, Ferrari C, Floreani A, Galli A, Giannini E, Grattagliano I, Lampertico P, Lleo A, Malinverno F, Mancuso C, Marra F, Marzioni M, Massironi S, Mattalia A, Miele L, Milani C, Morini L, Morisco F, Muratori L, Muratori P, Niro G, O’Donnell S, Picciotto A, Portincasa P, Rigamonti C, Ronca V, Rosina F, Spinzi G, Strazzabosco M, Tarocchi M, Tiribelli C, Toniutto P, Valenti L, Vinci M, Zuin M, Consortium J, Nakamura H, Abiru S, Nagaoka S, Komori A, Yatsuhashi H, Ishibashi H, Ito M, Migita K, Ohira H, Katsushima S, Naganuma A, Sugi K, Komatsu T, Mannami T, Matsushita K, Yoshizawa K, Makita F, Nikami T, Nishimura H, Kouno H, Kouno H, Ota H, Komura T, Nakamura Y, Shimada M, Hirashima N, Komeda T, Ario K, Nakamuta M, Yamashita T, Furuta K, Kikuchi M, Naeshiro N, Takahashi H, Mano Y, Tsunematsu S, Yabuuchi I, Shimada Y, Yamauchi K, Sugimoto R, Sakai H, Mita E, Koda M, Tsuruta S, Kamitsukasa H, Sato T, Masaki N, Kobata T, Fukushima N, Ohara Y, Muro T, Takesaki E, Takaki H, Yamamoto T, Kato M, Nagaoki Y, Hayashi S, Ishida J, Watanabe Y, Kobayashi M, Koga M, Saoshiro T, Yagura M, Hirata K, Tanaka A, Takikawa H, Zeniya M, Abe M, Onji M, Kaneko S, Honda M, Arai K, Arinaga-Hino T, Hashimoto E, Taniai M, Umemura T, Joshita S, Nakao K, Ichikawa T, Shibata H, Yamagiwa S, Seike M, Honda K, Sakisaka S, Takeyama Y, Harada M, Senju M, Yokosuka O, Kanda T, Ueno Y, Kikuchi K, Ebinuma H, Himoto T, Yasunami M, Murata K, Mizokami M, Kawata K, Shimoda S, Miyake Y, Takaki A, Yamamoto K, Hirano K, Ichida T, Ido A, Tsubouchi H, Chayama K, Harada K, Nakanuma Y, Maehara Y, Taketomi A, Shirabe K, Soejima Y, Mori A, Yagi S, Uemoto S, Egawa H, Tanaka T, Yamashiki N, Tamura S, Sugawara Y, Kokudo N, Consortium P, Atkinson E, de Andrade M, Chalasani N, Luketic V, Odin J, Chopra K, Baras A, Horowitz J, Abecasis G, Cantor M, Coppola G, Economides A, Lotta L, Overton J, Reid J, Shuldiner A, Beechert C, Forsythe C, Fuller E, Gu Z, Lattari M, Lopez A, Schleicher T, Padilla M, Toledo K, Widom L, Wolf S, Pradhan M, Manoochehri K, Ulloa R, Bai X, Balasubramanian S, Barnard L, Blumenfeld A, Eom G, Habegger L, Hawes A, Khalid S, Maxwell E, Salerno W, Staples J, Jones M, Mitnaul L, Consortium U, Sturgess R, Healey C, Yeoman A, Gunasekera A, Kooner P, Kapur K, Sathyanarayana V, Kallis Y, Subhani J, Harvey R, McCorry R, Rooney P, Ramanaden D, Evans R, Mathialahan T, Gasem J, Shorrock C, Bhalme M, Southern P, Tibble J, Gorard D, Jones S, Mells G, Mulcahy V, Srivastava B, Foxton M, Collins C, Elphick D, Karmo M, Porras-Perez F, Mendall M, Yapp T, Patel M, Ede R, Sayer J, Jupp J, Fisher N, Carter M, Koss K, Shah J, Piotrowicz A, Scott G, Grimley C, Gooding I, Williams S, Tidbury J, Lim G, Cheent K, Levi S, Mansour D, Beckley M, Hollywood C, Wong T, Marley R, Ramage J, Gordon H, Ridpath J, Ngatchu T, Grover V, Shidrawi R, Abouda G, Corless L, Narain M, Rees I, Brown A, Taylor-Robinson S, Wilkins J, Grellier L, Banim P, Das D, Heneghan M, Curtis H, Matthews H, Mohammed F, Aldersley M, Srirajaskanthan R, Walker G, McNair A, Sharif A, Sen S, Bird G, Prince M, Prasad G, Kitchen P, Barnardo A, Oza C, Sivaramakrishnan N, Gupta P, Shah A, Evans C, Saha S, Pollock K, Bramley P, Mukhopadhya A, Barclay S, McDonald N, Bathgate A, Palmer K, Dillon J, Rushbrook S, Przemioslo R, McDonald C, Millar A, Tai C, Mitchell S, Metcalf J, Shaukat S, Ninkovic M, Shmueli U, Davis A, Naqvi A, Lee T, Ryder S, Collier J, Klass H, Cramp M, Sharer N, Aspinall R, Ghosh D, Douds A, Booth J, Williams E, Hussaini H, Christie J, Mann S, Thorburn D, Marshall A, Patanwala I, Ala A, Maltby J, Matthew R, Corbett C, Vyas S, Singhal S, Gleeson D, Misra S, Butterworth J, George K, Harding T, Douglass A, Mitchison H, Panter S, Shearman J, Bray G, Roberts M, Butcher G, Forton D, Mahmood Z, Cowan M, Das D, Ch’ng C, Rahman M, Whatley G, Wesley E, Mandal A, Jain S, Pereira S, Wright M, Trivedi P, Gordon F, Unitt E, Palejwala A, Austin A, Vemala V, Grant A, Higham A, Brind A, Mathew R, Cox M, Ramakrishnan S, King A, Whalley S, Fraser J, Thomson S, Bell A, Wong V, Kia R, Gee I, Keld R, Ransford R, Gotto J, Millson C. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs. Journal Of Hepatology 2021, 75: 572-581. PMID: 34033851, PMCID: PMC8811537, DOI: 10.1016/j.jhep.2021.04.055.Peer-Reviewed Original ResearchConceptsChronic liver diseaseBiliary cholangitisLiver diseaseSmall intrahepatic bile ductsTreatment of PBCPrimary biliary cholangitisIntrahepatic bile ductsAdditional risk lociRisk lociPattern recognition receptorsLicensed medicationsT helperAutoimmune destructionEast Asian cohortsAutoimmune disordersBile ductAsian cohortEuropean cohortInadequate responseNovel therapiesDrug efficacy screeningHealthy individualsGenome-wide association studiesNumerous risk lociRecognition receptors
2017
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
Qiu A, Shen M, Buss C, Chong YS, Kwek K, Saw SM, Gluckman PD, Wadhwa PD, Entringer S, Styner M, Karnani N, Heim CM, O'Donnell KJ, Holbrook JD, Fortier MV, Meaney MJ. Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. Cerebral Cortex 2017, 27: 1-13. PMID: 28334351, PMCID: PMC6057508, DOI: 10.1093/cercor/bhx065.Peer-Reviewed Original ResearchMeSH KeywordsAsian PeopleBrainBrain MappingCohort StudiesComputational BiologyDepressive Disorder, MajorFemaleFetal DevelopmentGene Regulatory NetworksGenotypeGestational AgeHumansImage Processing, Computer-AssistedInfant, NewbornMagnetic Resonance ImagingMaleMaternal-Fetal RelationsPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsSocial ClassConceptsMaternal depressive symptomsDepressive symptomsHippocampal volumeRight amygdalaRight hippocampal volumeGlutamate receptor activityNeonatal brain developmentMajor depressive disorderRight amygdala volumeMother-infant dyadsFetal neurodevelopmentAmericas cohortAsian cohortDepressive disorderNeurotrophic signalingRight hippocampusCognitive-emotional functionRisk scoreAmygdala volumeSignificant interactionFetal developmentVentromedial prefrontal cortexSocio-economic statusBrain regionsReceptor activity
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