Abstract A137: Pharmacokinetics and pharmacodynamics of IGM-8444, a first-in-class engineered pentameric DR5-targeting agonist IgM monoclonal antibody, in patients with R/R and newly diagnosed cancers
Hernandez G, Bilic S, Guan Y, So J, Bhattacharya S, Wang B, Kotturi M, Oyasu M, Desbois M, Cao Y, Humke E, Ahern S, Sinclair A, Ulahannan S, Subbiah V, Pelster M, Lorusso P, Falchook G, Wang J, Barve M, Grewal J, Chow W, Henry J, Cecchini M, Takimoto C, Leabman M. Abstract A137: Pharmacokinetics and pharmacodynamics of IGM-8444, a first-in-class engineered pentameric DR5-targeting agonist IgM monoclonal antibody, in patients with R/R and newly diagnosed cancers. Molecular Cancer Therapeutics 2023, 22: a137-a137. DOI: 10.1158/1535-7163.targ-23-a137.Peer-Reviewed Original ResearchCleaved caspase-3Single agentNewly diagnosed cancerIgM monoclonal antibodyPreclinical mouse tumor modelsIgM antibodiesCASP-3Monoclonal antibodiesInduce tumor cell apoptosisPopulation PK modelPopulation PK analysisDose-dependent increaseMouse tumor modelsTumor cell apoptosisTerminal half-lifeTreatment-related increasesDose-dependent efficacyCleaved caspase-3 levelsEffects of ADAADA titersTwo-compartment modelPharmacodynamic changesTargeted therapyEfficacious dosePK analysisPrognosis and risk of suicide after cancer diagnosis
Kinslow C, Kumar P, Olfson M, Wall M, Petridis P, Horowitz D, Wang T, Kachnic L, Cheng S, Prigerson H, Yu J, Neugut A. Prognosis and risk of suicide after cancer diagnosis. Cancer 2023, 130: 588-596. PMID: 38018695, DOI: 10.1002/cncr.35118.Peer-Reviewed Original ResearchConceptsRisk of suicideCancer diagnosisSuicide riskCancer sitesMonths of diagnosisRelative risk of suicideSuicide deathsBaseline suicide riskSuicide ratesNewly diagnosed cancerYears of follow-upImpact of prognosisExistential distressAssociated with suicide riskMortality ratioWeighted linear regression modelImpending deathLinear regression modelsUS populationRelative riskGeneral populationBaseline riskAssociated with overall prognosisEnd Results databaseOverall survival ratePrognosis and risk of suicide after cancer diagnosis.
Kinslow C, Kumar P, Wall M, Prigerson H, Olfson M, Kachnic L, Horowitz D, Yu J, Cheng S, Neugut A. Prognosis and risk of suicide after cancer diagnosis. Journal Of Clinical Oncology 2023, 41: 6634-6634. DOI: 10.1200/jco.2023.41.16_suppl.6634.Peer-Reviewed Original ResearchRisk of suicideImpact of prognosisSuicide riskCancer sitesCancer diagnosisRelative risk of suicideBaseline riskNewly diagnosed cancerYears of follow-upRates of suicideMortality ratioU.S. cancersMonths of diagnosisWeighted linear regression modelLinear regression modelsPsychiatric referralRelative riskU.S. populationPersons ageTriage patientsSuicide ratesEnd ResultsBaseline rateIncreased surveillanceRegression models
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