Targeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium
Li T, Xi C, Yu Y, Wang N, Wang X, Iwasaki A, Fang F, Ding L, Li S, Zhang W, Yuan Y, Wang T, Yan X, He S, Cao Z, Naman C. Targeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium. Journal Of Natural Products 2022, 85: 493-500. PMID: 34986303, DOI: 10.1021/acs.jnatprod.1c00983.Peer-Reviewed Original ResearchConceptsChiral-phase HPLC analysisChemical degradationConfigurational assignmentDereplication toolLC-MS/MSTargeted isolationU937 human histiocytic lymphoma cellsTargeted discoveryGPCR targetsFilamentous cyanobacteriumNotable cytotoxicityOrganic extractsHuman histiocytic lymphoma cellsHistiocytic lymphoma cellsCompoundsHuman T lymphoblastoid cellsCXCR7 agonistPrimary cultured neocortical neuronsMethyl esterLymphoblastoid cellsMoleculesT-lymphoblastoid cellsCyanobacteriumNonapeptide analoguesΜM
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