2024
Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities
Valdez C, Sánchez-Zuno G, Bucala R, Tran T. Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities. International Journal Of Molecular Sciences 2024, 25: 4849. PMID: 38732068, PMCID: PMC11084905, DOI: 10.3390/ijms25094849.Peer-Reviewed Original ResearchConceptsInhibition of MIFResponse to infectionNon-canonical signaling pathwaysClinical studiesCancer patientsClinical trialsInflammatory cytokinesDriving tumorigenesisClinical explorationCancer typesCancerDual inhibitionTherapeutic targetIn vivoIn vitroSignaling pathwayMIFAntitumor candidateBinding partners
2017
Synthetic peptide TEKKRRETVEREKE derived from ezrin induces differentiation of NIH/3T3 fibroblasts
Chulkina M, Negmadjanov U, Lebedeva E, Pichugin A, Mazurov D, Ataullakhanov R, Holmuhamedov E. Synthetic peptide TEKKRRETVEREKE derived from ezrin induces differentiation of NIH/3T3 fibroblasts. European Journal Of Pharmacology 2017, 811: 249-259. PMID: 28668507, DOI: 10.1016/j.ejphar.2017.06.033.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DifferentiationCell MovementCollagen Type ICytoskeletal ProteinsFibroblastsGene Expression RegulationGene Knockout TechniquesHyaluronan ReceptorsIntracellular SpaceMiceNIH 3T3 CellsPeptide FragmentsProto-Oncogene Proteins c-fosSignal TransductionTransforming Growth Factor alphaConceptsIntracellular signaling pathwaysSignaling pathwayNon-canonical signaling pathwaysNIH/3T3 fibroblastsIntracellular actin filamentsActivation of intracellular signaling pathwaysNIH/3T3 cellsDependent signaling pathwayMAPK signaling pathwayActin filamentsInvestigate intracellular signaling pathwaysTreatment of fibroblastsERK1/2-dependent pathwayWild typeSmad-dependent signaling pathwayHinge regionStress filamentsERK1/2 kinasesMolecular mechanismsActivation of ERK1/2 kinasesMAPK pathwayNon-canonicalDependent pathwayCD44 receptorMouse fibroblasts
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