2017
Synthetic peptide TEKKRRETVEREKE derived from ezrin induces differentiation of NIH/3T3 fibroblasts
Chulkina M, Negmadjanov U, Lebedeva E, Pichugin A, Mazurov D, Ataullakhanov R, Holmuhamedov E. Synthetic peptide TEKKRRETVEREKE derived from ezrin induces differentiation of NIH/3T3 fibroblasts. European Journal Of Pharmacology 2017, 811: 249-259. PMID: 28668507, DOI: 10.1016/j.ejphar.2017.06.033.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DifferentiationCell MovementCollagen Type ICytoskeletal ProteinsFibroblastsGene Expression RegulationGene Knockout TechniquesHyaluronan ReceptorsIntracellular SpaceMiceNIH 3T3 CellsPeptide FragmentsProto-Oncogene Proteins c-fosSignal TransductionTransforming Growth Factor alphaConceptsIntracellular signaling pathwaysSignaling pathwayNon-canonical signaling pathwaysNIH/3T3 fibroblastsIntracellular actin filamentsActivation of intracellular signaling pathwaysNIH/3T3 cellsDependent signaling pathwayMAPK signaling pathwayActin filamentsInvestigate intracellular signaling pathwaysTreatment of fibroblastsERK1/2-dependent pathwayWild typeSmad-dependent signaling pathwayHinge regionStress filamentsERK1/2 kinasesMolecular mechanismsActivation of ERK1/2 kinasesMAPK pathwayNon-canonicalDependent pathwayCD44 receptorMouse fibroblasts
2010
Focal Increases of Fetal Macrophages in Placentas from Pregnancies with Histological Chorioamnionitis: Potential Role of Fibroblast Monocyte Chemotactic Protein‐1
Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven‐Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S. Focal Increases of Fetal Macrophages in Placentas from Pregnancies with Histological Chorioamnionitis: Potential Role of Fibroblast Monocyte Chemotactic Protein‐1. American Journal Of Reproductive Immunology 2010, 65: 470-479. PMID: 21087336, PMCID: PMC3071455, DOI: 10.1111/j.1600-0897.2010.00927.x.Peer-Reviewed Original ResearchConceptsHistopathological chorioamnionitisMCP-1 mRNAFocal increaseMonocyte chemotactic protein-1Subset of pregnanciesAdverse neonatal outcomesProtein expressionPro-inflammatory cytokinesMaternal-fetal interfaceChemotactic protein-1MCP-1 expressionTerm placental villiHistological chorioamnionitisNeonatal outcomesCytokine cascadeIL-1βInflammatory cytokinesQuantitative real-time PCRFetal monocytesReal-time PCRHuman term placental villiPlacental villiControl groupBacterial productsTreatment of fibroblasts
2001
Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms
Yarovinsky T, Hunninghake G. Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2001, 281: l1248-l1256. PMID: 11597917, DOI: 10.1152/ajplung.2001.281.5.l1248.Peer-Reviewed Original ResearchConceptsActivation-induced cell deathFibroblast-conditioned mediumT cellsLung fibroblastsFas/Fas ligand-dependent mechanismFas ligand-dependent mechanismMouse primary lung fibroblastsPGE2-dependent mechanismsImmobilized anti-CD3 antibodyAnti-CD3 antibodyActivation-induced deathPrimary lung fibroblastsLigand-dependent mechanismTreatment of fibroblastsCaspase-3Fas receptorAntiapoptotic activityIndomethacinCell deathInhibitory activityFibroblastsDeathFibroblast culturesCaspase-8Cells
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