2021
Simultaneous Engagement of Tumor and Stroma Targeting Antibodies by Engineered NK-92 Cells Expressing CD64 Controls Prostate Cancer Growth
Hintz H, Snyder K, Wu J, Hullsiek R, Dahlvang J, Hart G, Walcheck B, LeBeau A. Simultaneous Engagement of Tumor and Stroma Targeting Antibodies by Engineered NK-92 Cells Expressing CD64 Controls Prostate Cancer Growth. Cancer Immunology Research 2021, 9: 1270-1282. PMID: 34452926, PMCID: PMC9119026, DOI: 10.1158/2326-6066.cir-21-0178.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerAntibody-dependent cell-mediated cytotoxicityCastration-resistant prostate cancerEffector-target cell ratioNatural killer cellsCell-mediated cytotoxicityIsotype control antibodyNK-92 cellsCombination of mAbsNK-92MI cellsProstate cancer growthCalcium signal transducer 2NK cell linesTumor-associated calcium signal transducer 2Fibroblast activation protein alphaOverall survivalNK cellsCell activation mechanismsImmunotherapy responseKiller cellsNK-92MICombination therapyPrior sensitizationControl antibodyProstate cancer
1990
T-cell receptor-negative natural killer cells display antigen-specific cytotoxicity for microvascular endothelial cells.
Bender J, Pardi R, Engleman E. T-cell receptor-negative natural killer cells display antigen-specific cytotoxicity for microvascular endothelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 6949-6953. PMID: 2402485, PMCID: PMC54659, DOI: 10.1073/pnas.87.18.6949.Peer-Reviewed Original ResearchConceptsMicrovascular endothelial cellsEndothelial cellsNK cellsNatural killer cell targetsNatural killer cellsAllogeneic endothelial cellsAntigen-specific cytotoxicityNK cell linesCD3/T cell receptorLevel of adherenceEC linesHuman microvascular endothelial cellsT cell receptorOrgan allograftsGamma chain geneKiller cellsLymphoid cellsSpecific cytotoxicityCell targetsNegative cellsCell linesHuman erythroleukemia cellsSelective cytotoxicityTi moleculesCytotoxicity
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