2003
α4β2* Nicotinic Acetylcholine Receptors Modulate the Effects of Ethanol and Nicotine on the Acoustic Startle Response
Owens JC, Balogh SA, McClure‐Begley T, Butt CM, Labarca C, Lester HA, Picciotto MR, Wehner JM, Collins AC. α4β2* Nicotinic Acetylcholine Receptors Modulate the Effects of Ethanol and Nicotine on the Acoustic Startle Response. Alcohol Clinical And Experimental Research 2003, 27: 1867-1875. PMID: 14691373, DOI: 10.1097/01.alc.0000102700.72447.0f.Peer-Reviewed Original ResearchConceptsAcoustic startle responseEffects of ethanolLSxSS RIStartle responseAcoustic startleAlpha4beta2 nAChRsEthanol effectsBeta2 null mutant miceNeuronal nicotinic cholinergic receptorsEthanol-induced depressionNicotinic cholinergic receptorsPotential roleNicotinic acetylcholine receptorsNull mutant miceAlpha4 nAChRsCholinergic receptorsTobacco abuseNicotine effectsT polymorphismAcetylcholine receptorsLSXSS recombinantMutant miceBehavioral effectsNicotineStartle
2000
Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor
Verbitsky M, Rothlin C, Katz E, Elgoyhen A. Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor. Neuropharmacology 2000, 39: 2515-2524. PMID: 11044723, DOI: 10.1016/s0028-3908(00)00124-6.Peer-Reviewed Original ResearchConceptsOuter hair cellsCholinergic receptorsCholinergic compoundsAlpha9 nicotinic acetylcholine receptorHigh ACh concentrationsNicotinic cholinergic receptorsWeak partial agonistNicotinic acetylcholine receptorsCochlear outer hair cellsAgonist-evoked currentsAlpha9 receptorMuscarinic agonistsMaximal responseAcetylcholine receptorsPartial agonistACh concentrationPharmacological propertiesHair cellsReceptorsXenopus laevis oocytesAcetylcholineNative receptorAgonistsCompetitive typeLaevis oocytes
1988
Nicotinic Antagonists Enhance Process Outgrowth by Rat Retinal Ganglion Cells in Culture
Lipton S, Frosch M, Phillips M, Tauck D, Aizenman E. Nicotinic Antagonists Enhance Process Outgrowth by Rat Retinal Ganglion Cells in Culture. Science 1988, 239: 1293-1296. PMID: 3344435, DOI: 10.1126/science.3344435.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsNicotinic antagonistsGanglion cellsFunctional nicotinic cholinergic receptorsRetinal ganglion cell processesRat retinal ganglion cellsRetinal ganglion cell neuronsNicotinic cholinergic drugsSpecific nicotinic antagonistsProcess outgrowthGanglion cell neuronsNicotinic cholinergic receptorsGanglion cell processesNormal control mechanismsApplied acetylcholinePostsynaptic effectsCholinergic receptorsAmacrine cellsCholinergic drugsPharmacologic blockadeSpontaneous leaksRemoval of inhibitionRetinal culturesAcetylcholineCell neurons
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