2021
Mutations of the histone linker H1–4 in neurodevelopmental disorders and functional characterization of neurons expressing C-terminus frameshift mutant H1.4
Tremblay MW, Green MV, Goldstein BM, Aldridge AI, Rosenfeld JA, Streff H, Tan WD, Craigen W, Bekheirnia N, Al Tala S, West AE, Jiang YH. Mutations of the histone linker H1–4 in neurodevelopmental disorders and functional characterization of neurons expressing C-terminus frameshift mutant H1.4. Human Molecular Genetics 2021, 31: 1430-1442. PMID: 34788807, PMCID: PMC9271223, DOI: 10.1093/hmg/ddab321.Peer-Reviewed Original ResearchConceptsC-terminusGenome-wide transcriptome analysisRahman syndromeUnderstanding of mutationsHistone H1.4Neuronal genesTranscriptome analysisAbnormal C-terminusFunctional categoriesFunctional characterizationN-terminusNeuropeptide signalingDe novo heterozygous mutationsSupport of pathogenicitySmall insertionsFunctional consequencesNovo heterozygous mutationRat hippocampal neuronsFrameshift mutationMutationsH1.4Rare genetic disorderSevere intellectual disabilityGenesClinical features
2013
Pigment-Dispersing Factor Modulates Pheromone Production in Clock Cells that Influence Mating in Drosophila
Krupp JJ, Billeter JC, Wong A, Choi C, Nitabach MN, Levine JD. Pigment-Dispersing Factor Modulates Pheromone Production in Clock Cells that Influence Mating in Drosophila. Neuron 2013, 79: 54-68. PMID: 23849197, PMCID: PMC3955580, DOI: 10.1016/j.neuron.2013.05.019.Peer-Reviewed Original ResearchConceptsPigment Dispersing FactorClock cellsMating behaviorPheromone productionNeuropeptide Pigment Dispersing FactorPeripheral clock cellsMale sex pheromoneSex pheromone productionMolecular rhythmsPhysiological outputsNeuropeptide signalingBehavioral rhythmsCircadian mechanismsSex-specific differencesDrosophilaSex pheromoneCircadian entrainmentOenocytesCircadian systemPheromonePathwayNeuroendocrine pathwaysActivity rhythmsCellsBehavioral processes
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