1999
Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease
Baker C, Lu Z, Zaitsev I, Manuelidis L. Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease. Journal Of Virology 1999, 73: 5089-5097. PMID: 10233972, PMCID: PMC112554, DOI: 10.1128/jvi.73.6.5089-5097.1999.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseLysosomal protease cathepsin SCathepsin SMRNA expressionAbnormal PrP formationHost mRNA expressionUpregulation of CCR5Chemokine receptor CCR5Glial cell involvementGrowth factor beta1Microglial transcriptsNeuronal destructionProtease cathepsin SMicroglial activationAmyloid depositionPathogenetic pathwaysReceptor CCR5Cell involvementRodent modelsChronic reservoirDistinctive neuropathologyPleiotropic cytokineTGF-beta1Primary sitePrP pathology
1976
Serial propagation of Creutzfeldt-Jakob disease in guinea pigs.
Manuelidis E, Kim J, Angelo J, Manuelidis L. Serial propagation of Creutzfeldt-Jakob disease in guinea pigs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1976, 73: 223-227. PMID: 1108016, PMCID: PMC335873, DOI: 10.1073/pnas.73.1.223.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseGuinea pigsSubacute spongiform virus encephalopathiesSpongiform virus encephalopathiesHydrocephalus ex vacuoSubcortical gray structuresSerial propagationPercent takeNeuronal destructionCerebral atrophyNeuronal lossCerebral cortexEx vacuoGray structuresDiseaseSubsequent passagesPigsMorbidityAtrophyEncephalopathyIncubation periodInfectionMortalityCortexSymptomatology
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