2021
Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Harris J, Faust B, Gondin A, Dämgen M, Suomivuori C, Veldhuis N, Cheng Y, Dror R, Thal D, Manglik A. Selective G protein signaling driven by substance P–neurokinin receptor dynamics. Nature Chemical Biology 2021, 18: 109-115. PMID: 34711980, PMCID: PMC8712391, DOI: 10.1038/s41589-021-00890-8.Peer-Reviewed Original ResearchConceptsCryogenic-electron microscopy structuresG protein signalingGq signalingExtracellular loopG protein-coupled receptorsReceptor extracellular loopsSubstance PIntracellular signalingActive NK1RMolecular dynamics simulationsGs proteinPeptide interactionsGs signalingCognate receptorsStructural dynamicsReceptor dynamicsNeurokinin-1 receptorNeuropeptide substance PDynamics simulationsNK1R agonistNeurokinin-1ReceptorsNeurokinin ANK1RReceptor activation
2011
Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background.
Williams-Fritze MJ, Carlson Scholz JA, Zeiss C, Deng Y, Wilson SR, Franklin R, Smith PC. Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background. Journal Of The American Association For Laboratory Animal Science 2011, 50: 221-6. PMID: 21439216, PMCID: PMC3061423.Peer-Reviewed Original ResearchConceptsMaropitant citrateSubstance PUlcerative dermatitisC57BL/6 backgroundInhibition of SPCommon progressive conditionItch-scratch cycleNK1 receptor antagonistNeurokinin-1 receptorTachykinin neurokinin-1 receptorUD lesionsItch sensationExact etiologyInflamed skinReceptor antagonistNK1 receptorsProgressive conditionDorsal neckSkin traumaAdditional traumaTherapeutic interventionsImportant neuropeptideMiceDermatitisLesions
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply