Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Harris J, Faust B, Gondin A, Dämgen M, Suomivuori C, Veldhuis N, Cheng Y, Dror R, Thal D, Manglik A. Selective G protein signaling driven by substance P–neurokinin receptor dynamics. Nature Chemical Biology 2021, 18: 109-115. PMID: 34711980, PMCID: PMC8712391, DOI: 10.1038/s41589-021-00890-8.Peer-Reviewed Original ResearchConceptsCryogenic-electron microscopy structuresG protein signalingGq signalingExtracellular loopG protein-coupled receptorsReceptor extracellular loopsSubstance PIntracellular signalingActive NK1RMolecular dynamics simulationsGs proteinPeptide interactionsGs signalingCognate receptorsStructural dynamicsReceptor dynamicsNeurokinin-1 receptorNeuropeptide substance PDynamics simulationsNK1R agonistNeurokinin-1ReceptorsNeurokinin ANK1RReceptor activation
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