2024
Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder
Phalnikar K, Srividya M, Mythri S, Vasavi N, Ganguly A, Kumar A, S P, Kalia K, Mishra S, Dhanya S, Paul P, Holla B, Ganesh S, Reddy P, Sud R, Viswanath B, Muralidharan B. Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder. Oxford Open Neuroscience 2024, 3: kvae007. PMID: 38638145, PMCID: PMC11024480, DOI: 10.1093/oons/kvae007.Peer-Reviewed Original ResearchPatient organoidsNeural stem cellsBipolar disorderStem cellsTranscriptome analysis of controlPatient-derived organoidsFamilial bipolar disorderMigration defectsNeural stem cell culturesDysregulation of genesFamilial BDBD patientsCausative genetic variantsSox2-positiveNeurodevelopmental aberrationsNeurodevelopmental anomaliesIPSC-derived cerebral organoidsProgenitor proliferationStem cell culturesAbnormal positionPatientsNeuronal migrationCortical organoidsMolecular deficitsCycling progenitors
2020
Functional MRI Findings in Schizophrenia
Pearlson G. Functional MRI Findings in Schizophrenia. 2020, 113-124. DOI: 10.1007/978-3-030-35206-6_6.Peer-Reviewed Original ResearchSchizophrenia patientsDrug-naïve patientsFunctional MRI findingsFunctional MRI literatureTask-related paradigmsMRI findingsMedication treatmentPredisposing causeHealthy controlsFunctional abnormalitiesMRI reportsPsychotic bipolarNeurodevelopmental anomaliesPatientsBrain differencesUnaffected relativesSynaptic efficiencySchizophreniaMRI literatureAbnormalitiesArticle reviewsLocal manifestationsReviewSymptomsNeurotransmitters
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